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  • Exiguaquinol: A Novel Pentacyclic hydroquinone from Neopetrosia exigua that inhibits Helicobacter pylori MurI

    Author(s)
    Leone, Priscila de Almeida
    Carroll, Anthony R
    Towerzey, Leanne
    King, Gordon
    McArdle, Bernadette M
    Kern, Gunther
    Fisher, Stewart
    Hooper, John NA
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Carroll, Anthony R.
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC50 of 4.4 卮 Its structure and relative configuration were assigned on the basis of spectroscopic data. Exiguaquinol (2), bearing a novel pentacyclic ring skeleton, is the first natural product to show inhibition of H. pylori MurI. Its protein-ligand modeling is also discussed.Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC50 of 4.4 卮 Its structure and relative configuration were assigned on the basis of spectroscopic data. Exiguaquinol (2), bearing a novel pentacyclic ring skeleton, is the first natural product to show inhibition of H. pylori MurI. Its protein-ligand modeling is also discussed.
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    Journal Title
    Organic Letters
    Volume
    10
    Issue
    12
    DOI
    https://doi.org/10.1021/ol800898z
    Copyright Statement
    © 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Chemical sciences
    Publication URI
    http://hdl.handle.net/10072/23531
    Collection
    • Journal articles

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