Exiguaquinol: A Novel Pentacyclic hydroquinone from Neopetrosia exigua that inhibits Helicobacter pylori MurI
Author(s)
Leone, Priscila de Almeida
Carroll, Anthony R
Towerzey, Leanne
King, Gordon
McArdle, Bernadette M
Kern, Gunther
Fisher, Stewart
Hooper, John NA
Quinn, Ronald J
Year published
2008
Metadata
Show full item recordAbstract
Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC50 of 4.4 卮 Its structure and relative configuration were assigned on the basis of spectroscopic data. Exiguaquinol (2), bearing a novel pentacyclic ring skeleton, is the first natural product to show inhibition of H. pylori MurI. Its protein-ligand modeling is also discussed.Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC50 of 4.4 卮 Its structure and relative configuration were assigned on the basis of spectroscopic data. Exiguaquinol (2), bearing a novel pentacyclic ring skeleton, is the first natural product to show inhibition of H. pylori MurI. Its protein-ligand modeling is also discussed.
View less >
View less >
Journal Title
Organic Letters
Volume
10
Issue
12
Copyright Statement
© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Chemical sciences