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  • Prenylated Dihydrochalcones from Boronia bipinnata that Inhibit the Malarial Parasite Enzyme Target Hemoglobinase II

    Author(s)
    Carroll, Anthony R
    Fechner, Gregory A
    Smith, Jill
    Guymer, Gordon P
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Smith, Jill
    Carroll, Anthony R.
    Fechner, Gregory A.
    Year published
    2008
    Metadata
    Show full item record
    Abstract
    High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC50 values of 64 and 52 卬 respectively.High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC50 values of 64 and 52 卬 respectively.
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    Journal Title
    Journal of Natural Products
    Volume
    71
    Publisher URI
    http://pubs.acs.org/journal/jnprdf
    DOI
    https://doi.org/10.1021/np8002707
    Copyright Statement
    © 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Chemical sciences
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/23555
    Collection
    • Journal articles

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