Prenylated Dihydrochalcones from Boronia bipinnata that Inhibit the Malarial Parasite Enzyme Target Hemoglobinase II
Author(s)
Carroll, Anthony R
Fechner, Gregory A
Smith, Jill
Guymer, Gordon P
Quinn, Ronald J
Year published
2008
Metadata
Show full item recordAbstract
High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC50 values of 64 and 52 卬 respectively.High-throughput screening of a plant and marine invertebrate extract library to find natural products that inhibit the malarial parasite enzyme target hemoglobinase II led to the isolation of two new active prenylated chalcones, bipinnatones A (1) and B (2), from aerial parts of the Queensland shrub Boronia bipinnata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 inhibited hemoglobinase II with IC50 values of 64 and 52 卬 respectively.
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Journal Title
Journal of Natural Products
Volume
71
Publisher URI
Copyright Statement
© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine