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dc.contributor.authorCarroll, Anthony R
dc.contributor.authorLamb, Jasmine
dc.contributor.authorMoni, Roger
dc.contributor.authorGuymer, Gordon P
dc.contributor.authorForster, Paul I
dc.contributor.authorQuinn, Ronald J
dc.contributor.editorA Kinghorn Douglas
dc.date.accessioned2017-05-03T11:15:17Z
dc.date.available2017-05-03T11:15:17Z
dc.date.issued2008
dc.date.modified2010-11-02T07:05:11Z
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/10072/23566
dc.description.abstractHigh-throughput screening of a plant and marine invertebrate extract library to find natural products with rat thyrotropinreleasing hormone (TRH) receptor-2 binding affinity led to the isolation of four new, myrtucommulones F-I (3-6), and two known, myrtucommulones A (1) and D (2), active acylphloroglucinols from the seeds of the Queensland tree Corymbia scabrida. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. The relative configuration of the stereogenic centers for all six compounds was deduced from ROESY correlations. This is the first time that myrtucommulone A (1) has been isolated as a single pure compound. The structure of myrtucommulone D (2) has been revised. Myrtucommulones A, D, and F-I showed rat TRH receptor-2 binding affinity with IC50 values of 39, 11, 16, 24, 31, and 16 卬 respectively.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society of Pharmacognosy and American Chemical Society
dc.publisher.placeUnited States
dc.publisher.urihttp://pubs.acs.org/journal/jnprdf
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1564
dc.relation.ispartofpageto1568
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume71
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleMyrtucommulones F-I, phloroglucinols with thyrotropin-releasing hormone receptor-2 binding affinity from the seeds of Corymbia scabrida
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorCarroll, Anthony R.


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