dc.contributor.author | Carroll, Anthony R | |
dc.contributor.author | Lamb, Jasmine | |
dc.contributor.author | Moni, Roger | |
dc.contributor.author | Guymer, Gordon P | |
dc.contributor.author | Forster, Paul I | |
dc.contributor.author | Quinn, Ronald J | |
dc.contributor.editor | A Kinghorn Douglas | |
dc.date.accessioned | 2017-05-03T11:15:17Z | |
dc.date.available | 2017-05-03T11:15:17Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2010-11-02T07:05:11Z | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.uri | http://hdl.handle.net/10072/23566 | |
dc.description.abstract | High-throughput screening of a plant and marine invertebrate extract library to find natural products with rat thyrotropinreleasing hormone (TRH) receptor-2 binding affinity led to the isolation of four new, myrtucommulones F-I (3-6), and two known, myrtucommulones A (1) and D (2), active acylphloroglucinols from the seeds of the Queensland tree Corymbia scabrida. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. The relative configuration of the stereogenic centers for all six compounds was deduced from ROESY correlations. This is the first time that myrtucommulone A (1) has been isolated as a single pure compound. The structure of myrtucommulone D (2) has been revised. Myrtucommulones A, D, and F-I showed rat TRH receptor-2 binding affinity with IC50 values of 39, 11, 16, 24, 31, and 16 卬 respectively. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Society of Pharmacognosy and American Chemical Society | |
dc.publisher.place | United States | |
dc.publisher.uri | http://pubs.acs.org/journal/jnprdf | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1564 | |
dc.relation.ispartofpageto | 1568 | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 71 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Traditional, complementary and integrative medicine | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 4208 | |
dc.title | Myrtucommulones F-I, phloroglucinols with thyrotropin-releasing hormone receptor-2 binding affinity from the seeds of Corymbia scabrida | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information. | |
gro.date.issued | 2008 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Quinn, Ronald J. | |
gro.griffith.author | Carroll, Anthony R. | |