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  • Breast cancer stem cells: implications for therapy of breast cancer

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    53203_1.pdf (115.3Kb)
    Author(s)
    Morrison, Brian J
    Schmidt, Chris W
    Lakhani, Sunil R
    Reynolds, Brent A
    Lopez, J Alejandro
    Griffith University Author(s)
    Lopez Ramirez, Alejandro
    Year published
    2008
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    Abstract
    The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells ...
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    The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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    Journal Title
    Breast Cancer Research (Online Edition)
    Volume
    10
    Issue
    4
    Publisher URI
    http://breast-cancer-research.com/content/10/4/210/abstract/
    DOI
    https://doi.org/10.1186/bcr2111
    Copyright Statement
    © 2008 Morrison, et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Note
    Page numbers are not for citation purposes. Instead, this article has the unique article number of 10.
    Subject
    Tumour immunology
    Oncology and carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/23616
    Collection
    • Journal articles

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