dc.contributor.author | J. Lewis, Stephen | |
dc.contributor.author | L. Smith, Adrian | |
dc.contributor.author | G. Neduvelil, Joseph | |
dc.contributor.author | Stevenson, G. | |
dc.contributor.author | J. Lindon, Matthew | |
dc.contributor.author | Brian Jones, A. | |
dc.contributor.author | S. Shearman, Mark | |
dc.contributor.author | Beher, Dirk | |
dc.contributor.author | Clarke, Earl | |
dc.contributor.author | D. Best, Jonathan | |
dc.contributor.author | E. Peachey, James | |
dc.contributor.author | Harrison, Timothy | |
dc.contributor.author | Luis Castro, J. | |
dc.date.accessioned | 2017-05-03T16:57:53Z | |
dc.date.available | 2017-05-03T16:57:53Z | |
dc.date.issued | 2005 | |
dc.date.modified | 2009-07-27T07:01:51Z | |
dc.identifier.issn | 0960894X | |
dc.identifier.doi | 10.1016/j.bmcl.2004.10.062 | |
dc.identifier.uri | http://hdl.handle.net/10072/24885 | |
dc.description.abstract | A new series of y-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United Kingdom | |
dc.publisher.uri | http://www.sciencedirect.com/science/journal/0960894X | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 373 | |
dc.relation.ispartofpageto | 378 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Bioorganic & Medicinal Chemistry Letters | |
dc.relation.ispartofvolume | 15 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medical Biochemistry and Metabolomics not elsewhere classified | |
dc.subject.fieldofresearch | Medicinal and Biomolecular Chemistry | |
dc.subject.fieldofresearch | Organic Chemistry | |
dc.subject.fieldofresearch | Pharmacology and Pharmaceutical Sciences | |
dc.subject.fieldofresearchcode | 110199 | |
dc.subject.fieldofresearchcode | 0304 | |
dc.subject.fieldofresearchcode | 0305 | |
dc.subject.fieldofresearchcode | 1115 | |
dc.title | A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2005 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Stevenson, Graeme I. | |