Oxazolidinones as novel human CCR8 antagonists
Author(s)
Jin, Jian
Wang, Yonghui
Wang, Feng
K. Kerns, Jeffery
M. Vinader, Victoria
P. Hancock, Ashley
J. Lindon, Matthew
I. Stevenson, Graeme
M. Morrow, Dwight
Rao, Parvathi
Nguyen, Cuc
J. Barrett, Victoria
Browning, Chris
Hartmann, Guido
P. Andrew, David
M. Sarau, Henry
J. Foley, James
J. Jurewicz, Anthony
A. Fornwald, James
J. Harker, Andy
L. Moore, Michael
A. Rivero, Ralph
E. Belmonte, Kristen
E. Connor, Helen
Griffith University Author(s)
Year published
2007
Metadata
Show full item recordAbstract
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume
17
Issue
6
Publisher URI
Subject
Biochemistry and Cell Biology not elsewhere classified
Medicinal and Biomolecular Chemistry
Organic Chemistry
Pharmacology and Pharmaceutical Sciences