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  • Oxazolidinones as novel human CCR8 antagonists

    Author(s)
    Jin, Jian
    Wang, Yonghui
    Wang, Feng
    K. Kerns, Jeffery
    M. Vinader, Victoria
    P. Hancock, Ashley
    J. Lindon, Matthew
    I. Stevenson, Graeme
    M. Morrow, Dwight
    Rao, Parvathi
    Nguyen, Cuc
    J. Barrett, Victoria
    Browning, Chris
    Hartmann, Guido
    P. Andrew, David
    M. Sarau, Henry
    J. Foley, James
    J. Jurewicz, Anthony
    A. Fornwald, James
    J. Harker, Andy
    L. Moore, Michael
    A. Rivero, Ralph
    E. Belmonte, Kristen
    E. Connor, Helen
    Griffith University Author(s)
    Stevenson, Graeme I.
    Year published
    2007
    Metadata
    Show full item record
    Abstract
    High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    17
    Issue
    6
    Publisher URI
    http://www.sciencedirect.com/science/journal/0960894X
    DOI
    https://doi.org/10.1016/j.bmcl.2006.12.076
    Subject
    Biochemistry and Cell Biology not elsewhere classified
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/24886
    Collection
    • Journal articles

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