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dc.contributor.authorRockstroh, A.
dc.contributor.authorKlienert, A.
dc.contributor.authorGrosse, F.
dc.contributor.authorSoe, K.
dc.date.accessioned2017-05-03T16:57:48Z
dc.date.available2017-05-03T16:57:48Z
dc.date.issued2007
dc.date.modified2009-07-29T06:07:58Z
dc.identifier.issn09509232
dc.identifier.doi10.1038/sj.onc.1209766
dc.identifier.urihttp://hdl.handle.net/10072/24910
dc.description.abstractThe 'human topoisomerase I (htopoI) damage response' was reported to be triggered by various kinds of DNA lesions. Also, a high and persistent level of htopoI cleavage complexes correlated with apoptosis. In the present study, we demonstrate that DNA damage-independent induction of cell death using colcemid and tumor necrosis factor alpha is also accompanied by a strong htopoI response that correlates with the onset of apoptotic hallmarks. Consequently, these results suggest that htopoI cleavage complex formation may be caused by signaling pathways independent of the kind of cellular stress. Thus, protein interactions or signaling cascades induced by DNA damage or cellular stress might lead to the formation of stabilized cleavage complexes rather than the DNA lesion itself. Finally, we show that p53 not only plays a key role in the regulation of the htopoI response to UV-C irradiation but also to treatment with colcemid.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placenew York, United States of America
dc.publisher.urihttp://www.nature.com/onc/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom123
dc.relation.ispartofpageto131
dc.relation.ispartofissue1
dc.relation.ispartofjournalOceogene
dc.relation.ispartofvolume26
dc.rights.retentionY
dc.subject.fieldofresearchCellular Interactions (incl. Adhesion, Matrix, Cell Wall)
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode060106
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1112
dc.titleCellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorRockstroh, Anja


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