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  • The human topoisomerase I damage response plays a role in apoptosis

    Author(s)
    Soe, Kent
    Rockstroh, Anja
    Schache, Peter
    Grosse, Frank
    Griffith University Author(s)
    Rockstroh, Anja
    Year published
    2004
    Metadata
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    Abstract
    Previous studies have shown that human topoisomerase I cleavage complexes form as a response to various DNA damages in vivo, the so called human topoisomerase I "damage response". It was suggested that this damage response may play a role in DNA repair as well as in apoptosis, but only very few investigations have been done and the significance of the damage response still remains unclear. Here we demonstrate that human topoisomerase I cleavage complexes induced by high doses of UV irradiation are highly stable for up to 48 h. Furthermore, we show that human topoisomerase I cleavage complexes correlate with apoptosis. However, ...
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    Previous studies have shown that human topoisomerase I cleavage complexes form as a response to various DNA damages in vivo, the so called human topoisomerase I "damage response". It was suggested that this damage response may play a role in DNA repair as well as in apoptosis, but only very few investigations have been done and the significance of the damage response still remains unclear. Here we demonstrate that human topoisomerase I cleavage complexes induced by high doses of UV irradiation are highly stable for up to 48 h. Furthermore, we show that human topoisomerase I cleavage complexes correlate with apoptosis. However, at low UV doses the cleavage complex level was very low and the complexes were repaired. Surprisingly, we found that high levels of stable cleavage complexes were not only found in UV-irradiated cells but also in untreated cells that underwent apoptosis. A possible role of human topoisomerase I in apoptosis is discussed.
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    Journal Title
    DNA Repair
    Volume
    3
    Issue
    4
    Publisher URI
    http://www.sciencedirect.com/science/journal/15687864
    DOI
    https://doi.org/10.1016/j.dnarep.2003.12.003
    Subject
    Biochemistry and Cell Biology
    Publication URI
    http://hdl.handle.net/10072/24916
    Collection
    • Journal articles

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