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dc.contributor.authorSoe, Kent
dc.contributor.authorRockstroh, Anja
dc.contributor.authorSchache, Peter
dc.contributor.authorGrosse, Frank
dc.date.accessioned2017-05-03T16:57:48Z
dc.date.available2017-05-03T16:57:48Z
dc.date.issued2004
dc.date.modified2009-07-29T06:08:38Z
dc.identifier.issn15687864
dc.identifier.doi10.1016/j.dnarep.2003.12.003
dc.identifier.urihttp://hdl.handle.net/10072/24916
dc.description.abstractPrevious studies have shown that human topoisomerase I cleavage complexes form as a response to various DNA damages in vivo, the so called human topoisomerase I "damage response". It was suggested that this damage response may play a role in DNA repair as well as in apoptosis, but only very few investigations have been done and the significance of the damage response still remains unclear. Here we demonstrate that human topoisomerase I cleavage complexes induced by high doses of UV irradiation are highly stable for up to 48 h. Furthermore, we show that human topoisomerase I cleavage complexes correlate with apoptosis. However, at low UV doses the cleavage complex level was very low and the complexes were repaired. Surprisingly, we found that high levels of stable cleavage complexes were not only found in UV-irradiated cells but also in untreated cells that underwent apoptosis. A possible role of human topoisomerase I in apoptosis is discussed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeGermany
dc.publisher.urihttp://www.sciencedirect.com/science/journal/15687864
dc.relation.ispartofpagefrom387
dc.relation.ispartofpageto393
dc.relation.ispartofissue4
dc.relation.ispartofjournalDNA Repair
dc.relation.ispartofvolume3
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode0601
dc.titleThe human topoisomerase I damage response plays a role in apoptosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorRockstroh, Anja


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