Show simple item record

dc.contributor.authorL. Cook, Anthony
dc.contributor.authorSturm, Richard A.
dc.date.accessioned2017-05-03T16:57:49Z
dc.date.available2017-05-03T16:57:49Z
dc.date.issued2008
dc.date.modified2009-07-29T06:08:41Z
dc.identifier.issn1755148X
dc.identifier.doi10.1111/j.1755-148X.2008.00510.X
dc.identifier.urihttp://hdl.handle.net/10072/24917
dc.description.abstractSeveral parallels between stem cell biology and tumour behaviour have been discovered in recent times. Such commonality is apparent in the unlimited capacity for cell division together with the lack of a differentiated phenotype in embryonic and adult stem cells, traits shared with tumour cells. Differentiation is a tightly regulated process that is mediated by the actions of multiple transcription factor families. The POU domain-containing family of transcription factors contains multiple mammalian members divided into six classes, which can be expressed broadly or in a cell-specific manner, and which are regulators of cell fate decisions of many different lineages. Target gene regulation can occur via a POU factor acting alone, or in combination with other POU proteins, ubiquitous co-activators or co-repressors, or other lineage restricted transcription factors. Aberrant levels of POU proteins have been found in several malignancies, including melanoma, connecting the otherwise developmentally restricted gene regulatory functions of POU transcription factors to the critical determinants of malignant transformation. Here, we focus on the role of the BRN2 (POU3F2/N-Oct-3) transcription factor in the melanocytic lineage where it may co-ordinate normal developmental cues that can be re-activated in melanoma. Recent studies have shown BRN2 to be responsive to MAPK pathway activation and to modulate the levels of MITF so as to suppress the differentiated melanocytic phenotype and to enhance tumour metastasis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell
dc.publisher.placeDenmark
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom611
dc.relation.ispartofpageto626
dc.relation.ispartofissue6
dc.relation.ispartofjournalPigment Cell and Melanoma Research
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchRegenerative Medicine (incl. Stem Cells and Tissue Engineering)
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode100404
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titlePOU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorCook, Anthony


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record