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dc.contributor.authorQuinn, Ronald
dc.contributor.authorCamp, David
dc.date.accessioned2017-05-03T11:30:44Z
dc.date.available2017-05-03T11:30:44Z
dc.date.issued2008
dc.date.modified2009-08-04T06:17:37Z
dc.identifier.urihttp://hdl.handle.net/10072/24941
dc.description.abstractThe wealth of chemical diversity that has evolved with biological diversity has been used as a source of medicines by indigenous peoples for thousands of years.1,2 Research into natural products reached a peak in the period from 1970-80. Of the 877 small molecule New Chemical Entities (NCEs) arising between 1981 and 2007, around 50% were natural products, derived from, or inspired by them.3 However, by the 1990s research on natural products by the pharmaceutical industry was declining. This decline was due to various factors, including the low throughput of screening/isolation of natural product extracts. Drug discovery turned to high throughput screening of large libraries of pure compounds synthesised via combinatorial chemistry. Because the chemical diversity of these libraries was not always relevant to biological function, this approach was not as successful as hoped. The potential rewards from natural product drug discovery are massive despite being regarded by some as a risky, speculative "fishing expedition" with no guarantee of finding compounds of interest. Timelines, governed by the separation of compounds from extracts using bioassay-guided fractionation, are slower than alternative lead generation strategies. This presentation outlines various process improvements implemented at the Eskitis Institute that have streamlined the conventional biodiscovery paradigm. The efficiency gains facilitate delivery of novel chemical leads from NP screening within timelines expected by big pharma and complement HTS as a lead generation strategy. (1) Brohm, D. Angew. Chem. Int. Ed. Engl. 2002, 41, 307-311. (2) Breinbauer, R.; Vetter, I. R.; Waldmann, H. Angew. Chem., Int. Ed. 2002, 41, 2878-2890. (3) Newman, D. J.; Cragg, G. M.; J. Nat. Prod. Rep. 2007, 70, 461-477.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNo data provided
dc.publisher.urihttps://www.amsa.asn.au/
dc.publisher.urihttps://www.amsa.asn.au/conference/amsa2008_christchurch/index.php
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameAMSA2008 - Joint Conference with NZMSS
dc.relation.ispartofconferencetitleBioactives v bioproducts. The road from discovery to market.
dc.relation.ispartofdatefrom2008-07-07
dc.relation.ispartofdateto2008-07-10
dc.relation.ispartoflocationChristchurch, NZ
dc.rights.retentionY
dc.subject.fieldofresearchNatural Products Chemistry
dc.subject.fieldofresearchcode030502
dc.titleBioactives v bioproducts. The road from discovery to market.
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.rights.copyright© 2008 Australian Marine Sciences Association. For information about this conference please refer to the publisher's website or contact the authors.
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorCamp, David B.


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    Contains papers delivered by Griffith authors at national and international conferences.

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