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  • Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

    Author(s)
    Blomqvist, MEL
    Silburn, PA
    Buchanan, DD
    Andreasen, N
    Blennow, K
    Pedersen, NL
    Brookes, AJ
    Mellick, GD
    Prince, JA
    Griffith University Author(s)
    Mellick, George
    Year published
    2004
    Metadata
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    Abstract
    We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed ...
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    We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed significant evidence of association with AAO in an Australian PD case-control sample. Analyses were complemented with AAO data from two independent Swedish AD case samples, for which previously reported findings were replicated. Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner.
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    Journal Title
    Neurogenetics
    Volume
    5
    Issue
    2
    DOI
    https://doi.org/10.1007/s10048-004-0173-4
    Subject
    Genetics
    Neurosciences
    Cognitive and computational psychology
    Publication URI
    http://hdl.handle.net/10072/25089
    Collection
    • Journal articles

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