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dc.contributor.authorBlomqvist, MEL
dc.contributor.authorSilburn, PA
dc.contributor.authorBuchanan, DD
dc.contributor.authorAndreasen, N
dc.contributor.authorBlennow, K
dc.contributor.authorPedersen, NL
dc.contributor.authorBrookes, AJ
dc.contributor.authorMellick, GD
dc.contributor.authorPrince, JA
dc.date.accessioned2017-05-03T16:58:06Z
dc.date.available2017-05-03T16:58:06Z
dc.date.issued2004
dc.date.modified2009-08-11T05:52:55Z
dc.identifier.issn1364-6745
dc.identifier.doi10.1007/s10048-004-0173-4
dc.identifier.urihttp://hdl.handle.net/10072/25089
dc.description.abstractWe recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed significant evidence of association with AAO in an Australian PD case-control sample. Analyses were complemented with AAO data from two independent Swedish AD case samples, for which previously reported findings were replicated. Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer-Verlag
dc.publisher.placeGermany
dc.relation.ispartofpagefrom115
dc.relation.ispartofpageto119
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeurogenetics
dc.relation.ispartofvolume5
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.titleSequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George
gro.griffith.authorSilburn, Peter A.


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