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dc.contributor.authorMellick, GD
dc.contributor.authorMaraganore, DM
dc.contributor.authorSilburn, PA
dc.date.accessioned2017-05-03T16:58:05Z
dc.date.available2017-05-03T16:58:05Z
dc.date.issued2005
dc.date.modified2009-08-11T05:53:46Z
dc.identifier.issn0304-3940
dc.identifier.doi10.1016/j.neulet.2004.10.078
dc.identifier.urihttp://hdl.handle.net/10072/25101
dc.description.abstractIt remains unclear whether genetic variants in SNCA (the alpha-synuclein gene) alter risk for sporadic Parkinson's disease (PD). The polymorphic mixed sequence repeat (NACP-Rep1) in the promoter region of SNCA has been previously examined as a potential susceptibility factor for PD with conflicting results. We report genotype and allele distributions at this locus from 369 PD cases and 370 control subjects of European Australian ancestry, with alleles designated as -1, 0, +1, +2, and +3 as previously described. Allele frequencies designated (0) were less common in Australian cases compared to controls (OR = 0.80, 95% CI 0.62-1.03). Combined analysis including all previously published ancestral European Rep1 data yielded a highly significant association between the 0 allele and a reduced risk for PD (OR = 0.79, 95% CI 0.70-0.89, p = 0.0001). Further study must now proceed to examine in detail this interesting and biologically plausible genetic association.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom112
dc.relation.ispartofpageto116
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeuroscience Letters
dc.relation.ispartofvolume375
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleAustralian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George


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