Show simple item record

dc.contributor.authorSawant, PD
dc.contributor.authorWatson, G
dc.contributor.authorMyhra, S
dc.contributor.authorNicolau, D
dc.contributor.editorDan V. Nicolau
dc.date.accessioned2017-05-03T16:57:22Z
dc.date.available2017-05-03T16:57:22Z
dc.date.issued2005
dc.identifier.issn1605-7422
dc.identifier.doi10.1117/12.584142
dc.identifier.urihttp://hdl.handle.net/10072/25331
dc.description.abstractThe demand for polymer-based DNA microarrays will increase because of their cost-effectiveness, biocompatibility and easy processing. However not all polymers are ideal substrates because of different chemical interactions of polymeric substrates with the DNA molecules. Results from AFM analysis of DNA immobilised on polymeric surfaces are evaluated using fractality, Gaussian distribution and lateral force imaging. It has been found that the nanosize defects in the substrate, such as poly-l-lysine, plays an important role in the growth of DNA aggregates in a vertical direction, whereas the covalent binding of DNA molecules on NHS-functionalised cyclo-olefin copolymer leads to the lateral growth of DNA aggregates.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSPIE
dc.publisher.placeBellingham, WA, USA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameBiomedical Applications of Micro- and Nanoengineering II
dc.relation.ispartofconferencetitleProgress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.relation.ispartofdatefrom2004-12-13
dc.relation.ispartofdateto2004-12-15
dc.relation.ispartoflocationSydney
dc.relation.ispartofpagefrom153
dc.relation.ispartofpageto159
dc.relation.ispartofvolume5651
dc.rights.retentionY
dc.subject.fieldofresearchcode291599
dc.titleAFM analysis of the formation of DNA aggregates on Polymeric biochips
dc.typeConference output
dc.type.descriptionE1 - Conferences
dc.type.codeE - Conference Publications
gro.date.issued2015-05-31T22:17:37Z
gro.hasfulltextNo Full Text
gro.griffith.authorMyhra, Sverre
gro.griffith.authorWatson, Gregory S.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Conference outputs
    Contains papers delivered by Griffith authors at national and international conferences.

Show simple item record