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dc.contributor.authorAndrews, Katherine T
dc.contributor.authorGatton, Michelle L
dc.contributor.authorSkinner-Adams, Tina S
dc.contributor.authorMcCarthy, James S
dc.contributor.authorGardiner, Donald L
dc.description.abstractThe adverse effect of co-infection with HIV and malaria is becoming increasingly apparent. The importance of these interactions is illustrated by the mathematical modeling of L. J. Abu-Rabbad et al. ("Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa," 8 Dec. 2006, p. 1603), which predicts significant increases in the prevalence of both diseases due to an interaction between them. Theoretical models suggested that the effect of antimalarial chemotherapy on co-infected individuals would be a decline in both HIV and malaria prevalence. These findings assume that the effect of antimalarial chemotherapy on HIV infection is a shorter duration of raised HIV viral load after malaria infection. Although this is an important consideration, a number of studies have demonstrated direct effects of antimalarial drugs on HIV replication (1) and inhibition of Plasmodiumfalciparum development by HIV protease inhibitors (PIs) (2-4). Some HIV PIs act synergistically in vitro in combination with antimalarials (5). These direct drug effects have the potential to alter the complex interaction between malaria and HIV in co-infected individuals. Although HIV PIs are not currently recommended for first-line antiretroviral (ARV) therapy, they are likely to assume a greater role in ARV therapy in malaria-endemic regions as thermostable formulations of PIs are made available at significantly reduced cost (6), and as the need to combat ARV-induced drug resistance increases (7). We endorse the view of Abu-Raddad et al. that further studies are required to explore these interactions, particularly with respect to the effect of interventions with potential efficacy against both pathogens.
dc.publisherAmerican Association for the Advancement of Science
dc.publisher.placeUnited States
dc.titleHIV-Malaria Interactions: Don't Forget the Drugs
dc.typeJournal article
dc.type.descriptionC3 - Articles (Letter/ Note)
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorAndrews, Katherine T.
gro.griffith.authorSkinner-Adams, Tina
gro.griffith.authorGardiner, Donald

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