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  • Antiretrovirals as antimalarial agents

    Author(s)
    S. Skinner-Adams, Tina
    S. McCarthy, James
    L. Gardiner, Donald
    M. Hilton, Petrina
    T. Andrews, Katherine
    Griffith University Author(s)
    Andrews, Katherine T.
    Skinner-Adams, Tina
    Year published
    2004
    Metadata
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    Abstract
    Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral agents. Our data indicate that, in addition to the previously published effects on cytoadherence and phagocytosis, the human immunodeficiency virus (HIV)-1 protease inhibitors saquinavir, ritonavir, and indinavir directly inhibit the growth of Plasmodium falciparum in vitro at clinically relevant concentrations. These findings are particularly important in light of both the high rate of malaria and HIV-1 coinfection in sub-Saharan ...
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    Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral agents. Our data indicate that, in addition to the previously published effects on cytoadherence and phagocytosis, the human immunodeficiency virus (HIV)-1 protease inhibitors saquinavir, ritonavir, and indinavir directly inhibit the growth of Plasmodium falciparum in vitro at clinically relevant concentrations. These findings are particularly important in light of both the high rate of malaria and HIV-1 coinfection in sub-Saharan Africa and the effort to employ highly active antiretroviral therapy in these regions.
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    Journal Title
    The Journal of Infectious Diseases
    Volume
    190
    Issue
    11
    DOI
    https://doi.org/10.1086/425584
    Subject
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/25415
    Collection
    • Journal articles

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