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  • FGF2 Promotes Neuronal Differentiation in Explant Cultures of Adult and Embryonic Mouse Olfactory Epithelium

    Author(s)
    MacDonald, KPA
    Murrell, WG
    Bartlett, PF
    Bushell, GR
    MackaySim, A
    Griffith University Author(s)
    Bushell, Gillian R.
    Mackay-Sim, Alan
    Year published
    1996
    Metadata
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    Abstract
    Neurogenesis in the adult olfactory epithelium is highly regulated in vivo. Little is known of the molecular signals which control this process, although contact with the olfactory bulb or with astrocytes has been implicated. Explants of mouse olfactory epithelium were grown in the presence or absence of several peptide growth factors. Basic fibroblast growth factor (FGF2) stimulated differentiation of sensory neurons in adult and embryonic olfactory epithelium. Other growth factors tested were ineffective. FGF2-stimulated neurons were born in vitro and expressed neurofilament, neural cell adhesion molecule, and -tubulin. ...
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    Neurogenesis in the adult olfactory epithelium is highly regulated in vivo. Little is known of the molecular signals which control this process, although contact with the olfactory bulb or with astrocytes has been implicated. Explants of mouse olfactory epithelium were grown in the presence or absence of several peptide growth factors. Basic fibroblast growth factor (FGF2) stimulated differentiation of sensory neurons in adult and embryonic olfactory epithelium. Other growth factors tested were ineffective. FGF2-stimulated neurons were born in vitro and expressed neurofilament, neural cell adhesion molecule, and -tubulin. The cells also expressed olfactory marker protein, a marker for mature olfactory sensory neurons in vivo. These bipolar neurons did not express glial fibrillary acidic protein or low-affinity nerve growth factor receptor. These results indicate that neither astrocytes nor olfactory bulb are necessary for differentiation of olfactory sensory neurons in vitro. 頱996 Wiley-Liss, Inc.
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    Journal Title
    Journal of Neuroscience Research
    Volume
    44
    Publisher URI
    https://onlinelibrary.wiley.com/toc/10974547/1996/44/1
    DOI
    https://doi.org/10.1002/(SICI)1097-4547(19960401)44:1<27::AID-JNR4>3.0.CO;2-K
    Copyright Statement
    © 1996 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
    Subject
    Neurosciences
    Biological psychology
    Publication URI
    http://hdl.handle.net/10072/25723
    Collection
    • Journal articles

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