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dc.contributor.authorMacDonald, Kellien_US
dc.contributor.authorMurrell, Wayneen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.authorBushell, Gillianen_US
dc.contributor.authorBartlett, P.en_US
dc.date.accessioned2017-04-24T10:46:43Z
dc.date.available2017-04-24T10:46:43Z
dc.date.issued1996en_US
dc.date.modified2009-09-21T05:47:40Z
dc.identifier.issn03604012en_US
dc.identifier.doi10.1002/(SICI)1097-4547(19960401)44:1<27::AID-JNR4>3.0.CO;2-Ken_AU
dc.identifier.urihttp://hdl.handle.net/10072/25723
dc.description.abstractNeurogenesis in the adult olfactory epithelium is highly regulated in vivo. Little is known of the molecular signals which control this process, although contact with the olfactory bulb or with astrocytes has been implicated. Explants of mouse olfactory epithelium were grown in the presence or absence of several peptide growth factors. Basic fibroblast growth factor (FGF2) stimulated differentiation of sensory neurons in adult and embryonic olfactory epithelium. Other growth factors tested were ineffective. FGF2-stimulated neurons were born in vitro and expressed neurofilament, neural cell adhesion molecule, and -tubulin. The cells also expressed olfactory marker protein, a marker for mature olfactory sensory neurons in vivo. These bipolar neurons did not express glial fibrillary acidic protein or low-affinity nerve growth factor receptor. These results indicate that neither astrocytes nor olfactory bulb are necessary for differentiation of olfactory sensory neurons in vitro. 頱996 Wiley-Liss, Inc.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherJohn Wiley & Sonsen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://www3.interscience.wiley.com/journal/34828/homeen_AU
dc.relation.ispartofpagefrom27en_US
dc.relation.ispartofpageto39en_US
dc.relation.ispartofjournalJournal of Neuroscience Researchen_US
dc.relation.ispartofvolume44en_US
dc.subject.fieldofresearchTECHNOLOGYen_US
dc.subject.fieldofresearchcode100000en_US
dc.titleFGF2 Promotes Neuronal Differentiation in Explant Cultures of Adult and Embryonic Mouse Olfactory Epitheliumen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.rights.copyrightCopyright 1996 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.en_AU
gro.date.issued1996
gro.hasfulltextNo Full Text


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