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dc.contributor.authorMacDonald, KPA
dc.contributor.authorMurrell, WG
dc.contributor.authorBartlett, PF
dc.contributor.authorBushell, GR
dc.contributor.authorMackaySim, A
dc.date.accessioned2017-05-03T13:36:48Z
dc.date.available2017-05-03T13:36:48Z
dc.date.issued1996
dc.date.modified2009-09-21T05:47:40Z
dc.identifier.issn0360-4012
dc.identifier.doi10.1002/(SICI)1097-4547(19960401)44:1<27::AID-JNR4>3.0.CO;2-K
dc.identifier.urihttp://hdl.handle.net/10072/25723
dc.description.abstractNeurogenesis in the adult olfactory epithelium is highly regulated in vivo. Little is known of the molecular signals which control this process, although contact with the olfactory bulb or with astrocytes has been implicated. Explants of mouse olfactory epithelium were grown in the presence or absence of several peptide growth factors. Basic fibroblast growth factor (FGF2) stimulated differentiation of sensory neurons in adult and embryonic olfactory epithelium. Other growth factors tested were ineffective. FGF2-stimulated neurons were born in vitro and expressed neurofilament, neural cell adhesion molecule, and -tubulin. The cells also expressed olfactory marker protein, a marker for mature olfactory sensory neurons in vivo. These bipolar neurons did not express glial fibrillary acidic protein or low-affinity nerve growth factor receptor. These results indicate that neither astrocytes nor olfactory bulb are necessary for differentiation of olfactory sensory neurons in vitro. 頱996 Wiley-Liss, Inc.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUSA
dc.publisher.urihttps://onlinelibrary.wiley.com/toc/10974547/1996/44/1
dc.relation.ispartofpagefrom27
dc.relation.ispartofpageto39
dc.relation.ispartofjournalJournal of Neuroscience Research
dc.relation.ispartofvolume44
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5202
dc.titleFGF2 Promotes Neuronal Differentiation in Explant Cultures of Adult and Embryonic Mouse Olfactory Epithelium
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 1996 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
gro.date.issued1996
gro.hasfulltextNo Full Text
gro.griffith.authorBushell, Gillian R.
gro.griffith.authorMackay-Sim, Alan


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