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dc.contributor.authorFeron, F
dc.contributor.authorVincent, A
dc.contributor.authorMackay-Sim, A
dc.date.accessioned2017-05-03T13:43:29Z
dc.date.available2017-05-03T13:43:29Z
dc.date.issued1999
dc.date.modified2009-09-22T05:51:34Z
dc.identifier.issn0006-8993
dc.identifier.doi10.1016/S0006-8993(99)01959-9
dc.identifier.urihttp://hdl.handle.net/10072/25754
dc.description.abstractIn two previous in vitro experiments, we have shown that dopamine induced apoptosis or differentiation in an olfactory cell line while it reduced mitosis and triggered cell death in human olfactory biopsy cultures. The aims of the present study were to locate precisely D2 dopamine receptors within the olfactory epithelium and to monitor the effect of dopamine on olfactory neuronal differentiation in explant cultures. We show here that D2 dopamine receptors are expressed in supporting cells, neurons and basal cells in the olfactory epithelium. In vitro, dopamine was found to (1) trigger neuronal differentiation and maturation in a dose-dependent manner via D2 dopamine receptors, (2) be active only when not oxidised, (3) act directly on epithelial cells and not through other reactive cells in the underlying lamina propria. Altogether these data indicate that, in parallel to its action in odour processing, dopamine plays a growth factor-like role in the permanent neurogenesis observed in the olfactory epithelium.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00068993
dc.relation.ispartofpagefrom252
dc.relation.ispartofpageto259
dc.relation.ispartofjournalBrain Research
dc.relation.ispartofvolume845
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleDopamine Promotes differentiation of Olfactory neuron in vitro
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued1999
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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