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dc.contributor.authorFeron, Francoisen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.date.accessioned2017-05-03T13:43:29Z
dc.date.available2017-05-03T13:43:29Z
dc.date.issued1999en_US
dc.date.modified2009-09-22T05:51:34Z
dc.identifier.issn00068993en_US
dc.identifier.doi10.1016/S0006-8993(99)01959-9en_AU
dc.identifier.urihttp://hdl.handle.net/10072/25754
dc.description.abstractIn two previous in vitro experiments, we have shown that dopamine induced apoptosis or differentiation in an olfactory cell line while it reduced mitosis and triggered cell death in human olfactory biopsy cultures. The aims of the present study were to locate precisely D2 dopamine receptors within the olfactory epithelium and to monitor the effect of dopamine on olfactory neuronal differentiation in explant cultures. We show here that D2 dopamine receptors are expressed in supporting cells, neurons and basal cells in the olfactory epithelium. In vitro, dopamine was found to (1) trigger neuronal differentiation and maturation in a dose-dependent manner via D2 dopamine receptors, (2) be active only when not oxidised, (3) act directly on epithelial cells and not through other reactive cells in the underlying lamina propria. Altogether these data indicate that, in parallel to its action in odour processing, dopamine plays a growth factor-like role in the permanent neurogenesis observed in the olfactory epithelium.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Scienceen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00068993en_AU
dc.relation.ispartofpagefrom252en_US
dc.relation.ispartofpageto259en_US
dc.relation.ispartofjournalBrain Researchen_US
dc.relation.ispartofvolume845en_US
dc.titleDopamine Promotes differentiation of Olfactory neuron in vitroen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued1999
gro.hasfulltextNo Full Text


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