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dc.contributor.authorMurrell, Wayneen_US
dc.contributor.authorBushell, Gillianen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.contributor.authorBates, Paulen_US
dc.contributor.authorMacDonald, Kellien_US
dc.contributor.authorLivesey, Jonathonen_US
dc.contributor.authorMcGrath, Johnen_US
dc.date.accessioned2017-04-24T10:46:45Z
dc.date.available2017-04-24T10:46:45Z
dc.date.issued1996en_US
dc.date.modified2009-09-22T05:52:20Z
dc.identifier.issn09594965en_US
dc.identifier.doihttp://www.ncbi.nlm.nih.gov/pubmed/8817530en_AU
dc.identifier.urihttp://hdl.handle.net/10072/25758
dc.description.abstractTHIS report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not glial proteins. [3H]thymidine autoradiography confirmed that these neurones were born in vitro. The results demonstrate that the adult human olfactory epithelium retains the capacity for neurogenesis and neuronal differentiation, at least until the age of 72 years. It is now possible to examine neurones and neurogenesis in biopsies from patients with disorders that may involve a neurodevelopmental or neurodegenerative aetiology such as schizophrenia, bipolar disorder and Alzheimer's disease.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherS. Kargeren_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://journals.lww.com/neuroreport/pages/default.aspxen_AU
dc.relation.ispartofpagefrom1189en_US
dc.relation.ispartofpageto1194en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalDevelopmental Neuroscienceen_US
dc.relation.ispartofvolume7en_US
dc.subject.fieldofresearchTECHNOLOGYen_US
dc.subject.fieldofresearchcode100000en_US
dc.titleNeurogenesis in Adult Humanen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued1996
gro.hasfulltextNo Full Text


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