dc.contributor.author | Ashman, Robert | |
dc.contributor.author | Farah, Camile | |
dc.contributor.author | Wanasaengsakul, Siripen | |
dc.contributor.author | Hu, Yan | |
dc.contributor.author | Pang, Gerald | |
dc.contributor.author | Clancy, Robert | |
dc.date.accessioned | 2017-05-03T16:58:28Z | |
dc.date.available | 2017-05-03T16:58:28Z | |
dc.date.issued | 2004 | |
dc.date.modified | 2009-09-24T05:52:07Z | |
dc.identifier.issn | 08189641 | |
dc.identifier.doi | 10.1046/j.0818-9641.2004.01217.x | |
dc.identifier.uri | http://hdl.handle.net/10072/25781 | |
dc.description.abstract | Candida albicans is a common opportunistic pathogen, causing both superficial and systemic infection. Clinical observations indicate that mucocutaneous infections are commonly associated with defective cell-mediated immune responses, whereas systemic infection is more frequently seen in patients with deficiencies in neutrophil number or function. Analysis of mechanisms of host resistance against gastrointestinal and oral infection in mouse models has demonstrated an absolute dependence on CD4+ T cells, although clearance also involves phagocytic cells. Both IL-12 and TNF- appear to be important mediators, but mouse strain-dependent variations in susceptibility to infection may be related to T-cell enhancement of production of phagocytic cells by the bone marrow. In murine systemic infection, the role of innate and adaptive responses is less well defined. Studies in immunodeficient and T-cell-depleted mice suggest that clearance of the yeast may be predominantly a function of the innate response, whereas the adaptive response may either limit tissue damage or have the potential to cause immunopathology, depending on the host genetic context in which the infection takes place. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofpagefrom | 196 | |
dc.relation.ispartofpageto | 204 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Immunology and Cell Biology | |
dc.relation.ispartofvolume | 82 | |
dc.subject.fieldofresearch | Biochemistry and Cell Biology | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearchcode | 0601 | |
dc.subject.fieldofresearchcode | 1107 | |
dc.title | Innate versus adaptive immunity in Candida albicans infection | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2004 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Ashman, Robert B. | |