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dc.contributor.authorAshman, Robert
dc.contributor.authorFarah, Camile
dc.contributor.authorWanasaengsakul, Siripen
dc.contributor.authorHu, Yan
dc.contributor.authorPang, Gerald
dc.contributor.authorClancy, Robert
dc.date.accessioned2017-05-03T16:58:28Z
dc.date.available2017-05-03T16:58:28Z
dc.date.issued2004
dc.date.modified2009-09-24T05:52:07Z
dc.identifier.issn08189641
dc.identifier.doi10.1046/j.0818-9641.2004.01217.x
dc.identifier.urihttp://hdl.handle.net/10072/25781
dc.description.abstractCandida albicans is a common opportunistic pathogen, causing both superficial and systemic infection. Clinical observations indicate that mucocutaneous infections are commonly associated with defective cell-mediated immune responses, whereas systemic infection is more frequently seen in patients with deficiencies in neutrophil number or function. Analysis of mechanisms of host resistance against gastrointestinal and oral infection in mouse models has demonstrated an absolute dependence on CD4+ T cells, although clearance also involves phagocytic cells. Both IL-12 and TNF- appear to be important mediators, but mouse strain-dependent variations in susceptibility to infection may be related to T-cell enhancement of production of phagocytic cells by the bone marrow. In murine systemic infection, the role of innate and adaptive responses is less well defined. Studies in immunodeficient and T-cell-depleted mice suggest that clearance of the yeast may be predominantly a function of the innate response, whereas the adaptive response may either limit tissue damage or have the potential to cause immunopathology, depending on the host genetic context in which the infection takes place.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom196
dc.relation.ispartofpageto204
dc.relation.ispartofissue2
dc.relation.ispartofjournalImmunology and Cell Biology
dc.relation.ispartofvolume82
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1107
dc.titleInnate versus adaptive immunity in Candida albicans infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorAshman, Robert B.


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