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  • Sarcolemmal KATP channel triggers opioid-induced delayed cardioprotection in the rat

    Author(s)
    Patel, Hemal
    K. Hsu, Anna
    N. Peart, Jason
    J. Gross, Garrett
    Griffith University Author(s)
    Peart, Jason N.
    Year published
    2002
    Metadata
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    Abstract
    Recently, the involvement of sarcolemmal KATP (sarcKATP) channels in ischemic and pharmacological preconditioning (IPC and PPC) has been minimized by numerous studies suggesting a primary role for mitochondrial KATP (mitoKATP) channels in early and delayed cardioprotection. Although the mitoKATP channel has clearly been shown to be a distal effector of delayed IPC and PPC, studies implicating it as a trigger of protection in delayed IPC are lacking. Accordingly, we characterized the role of cardiac KATP channels as triggerRecently, the involvement of sarcolemmal KATP (sarcKATP) channels in ischemic and pharmacological preconditioning (IPC and PPC) has been minimized by numerous studies suggesting a primary role for mitochondrial KATP (mitoKATP) channels in early and delayed cardioprotection. Although the mitoKATP channel has clearly been shown to be a distal effector of delayed IPC and PPC, studies implicating it as a trigger of protection in delayed IPC are lacking. Accordingly, we characterized the role of cardiac KATP channels as trigger
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    Journal Title
    Circulation Research
    Volume
    91
    Issue
    3
    DOI
    https://doi.org/10.1161/01.RES.0000029085.69891.F2
    Subject
    Cardiorespiratory Medicine and Haematology
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/25801
    Collection
    • Journal articles

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