Sarcolemmal KATP channel triggers opioid-induced delayed cardioprotection in the rat
Author(s)
Patel, Hemal
K. Hsu, Anna
N. Peart, Jason
J. Gross, Garrett
Griffith University Author(s)
Year published
2002
Metadata
Show full item recordAbstract
Recently, the involvement of sarcolemmal KATP (sarcKATP) channels in ischemic and pharmacological preconditioning (IPC and PPC) has been minimized by numerous studies suggesting a primary role for mitochondrial KATP (mitoKATP) channels in early and delayed cardioprotection. Although the mitoKATP channel has clearly been shown to be a distal effector of delayed IPC and PPC, studies implicating it as a trigger of protection in delayed IPC are lacking. Accordingly, we characterized the role of cardiac KATP channels as triggerRecently, the involvement of sarcolemmal KATP (sarcKATP) channels in ischemic and pharmacological preconditioning (IPC and PPC) has been minimized by numerous studies suggesting a primary role for mitochondrial KATP (mitoKATP) channels in early and delayed cardioprotection. Although the mitoKATP channel has clearly been shown to be a distal effector of delayed IPC and PPC, studies implicating it as a trigger of protection in delayed IPC are lacking. Accordingly, we characterized the role of cardiac KATP channels as trigger
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Journal Title
Circulation Research
Volume
91
Issue
3
Subject
Cardiorespiratory Medicine and Haematology
Clinical Sciences