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dc.contributor.authorUlett, GC
dc.contributor.authorNorton, RE
dc.contributor.authorHirst, RG
dc.date.accessioned2017-05-03T15:29:42Z
dc.date.available2017-05-03T15:29:42Z
dc.date.issued1999
dc.date.modified2009-09-29T23:12:19Z
dc.identifier.issn0031-3025
dc.identifier.doi10.1080/003130299105106
dc.identifier.urihttp://hdl.handle.net/10072/25821
dc.description.abstractBurkholderia pseudomallei is the causative agent of melioidosis, a disease endemic in tropical and subtropical regions of South-East Asia and Northern Australia. Antimicrobial therapy regimens for treatment of acute septicemic melioidosis are of variable efficacy. Ceftazidime is the current antibiotic of choice and is commonly administered with other agents such as cotrimoxazole or doxycycline. The emergence of resistant strains of B. pseudomallei and the persistence of high mortality rates prompted the present study. Using an established mouse model of acute disseminated B. pseudomallei infection, we compared the efficacy of ceftazidime versus cefpirome in combination with cotrimoxazole or chloramphenicol therapy in vivo. Control mice that were infected but did not receive antibiotic therapy died within 96 hours of infection. No deaths occurred in treatment groups receiving either cephalosporin or cotrimoxazole, despite the demonstrated resistance of B. pseudomallei to cotrimoxazole in vitro. The mortality rate in treatment groups receiving either cephalosporin and chloramphenicol was 66%. These results demonstrate a comparable level of efficacy between ceftazidime and cefpirome for treatment of acute B. pseudomallei infection in mice.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherInforma Healthcare
dc.publisher.placeUK
dc.publisher.urihttp://www.informaworld.com/smpp/title~content=t713440474
dc.relation.ispartofpagefrom264
dc.relation.ispartofpageto267
dc.relation.ispartofissue3
dc.relation.ispartofjournalPathology
dc.relation.ispartofvolume31
dc.subject.fieldofresearchMedical Bacteriology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110801
dc.subject.fieldofresearchcode1103
dc.titleCombination Antimicrobial Therapy of Acute Burkholderia pseudomallei Infection in a Mouse Model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 1999 Taylor & Francis. Please refer to the journal's website for access to the definitive, published version.This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.
gro.date.issued1999
gro.hasfulltextNo Full Text
gro.griffith.authorUlett, Glen C.


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