Show simple item record

dc.contributor.authorUlett, GC
dc.contributor.authorKetheesan, N
dc.contributor.authorHirst, RG
dc.date.accessioned2017-05-03T15:29:24Z
dc.date.available2017-05-03T15:29:24Z
dc.date.issued2000
dc.identifier.issn0001-706X
dc.identifier.doi10.1016/S0001-706X(99)00075-3
dc.identifier.urihttp://hdl.handle.net/10072/25822
dc.description.abstractMelioidosis is a potentially fatal disease of both human and animals caused by the bacterium Burkholderia pseudomallei. Disease is endemic in tropical and subtropical regions of Southeast Asia and Northern Australia. The pathogenesis of melioidosis is poorly understood. In particular, the host responses that occur following infection, and the specific host-pathogen interactions that result in the development of either acute or chronic infection are unclear. Using an established murine model, we investigated early proinflammatory cytokine responses believed to be critical in the development of acute and chronic B. pseudomallei infection. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to assess levels of mRNA for tumor necrosis factor-a (TNF-a), interleukin 1b (IL-1b) and interleukin 6 (IL-6) in the liver of mice following infection. We demonstrate that the level of mRNA for these cytokines increase moderately in chronic infection in C57BL/6 mice. However, in acute infection in BALB/c mice, mRNA responses for these cytokines were shown to be comparatively greater. These results demonstrate that early proinflammatory cytokine responses are important in the immunopathogenesis of melioidosis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeThe Netherlands
dc.relation.ispartofpagefrom229
dc.relation.ispartofpageto234
dc.relation.ispartofissue2
dc.relation.ispartofjournalActa Tropica
dc.relation.ispartofvolume74
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320701
dc.titleProinflammatory Cytokine mRNA Responses in Experimental Burkholderia pseudomallei Infection in Mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-01-30T00:43:34Z
gro.hasfulltextNo Full Text
gro.griffith.authorUlett, Glen C.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record