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  • A Comparison of Antibiotic Regimens in the Treatment of Acute Melioidosis in a Mouse Model

    Author(s)
    Ulett, GC
    Hirst, R
    Bowden, B
    Powell, K
    Norton, R
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    2003
    Metadata
    Show full item record
    Abstract
    Melioidosis is caused by the Gram-negative bacillus Burkholderia pseudomallei. Most clinical reports of disease are from south-east Asia and northern Australia. The organism is intrinsically resistant to most commonly available antibiotics. Standard therapy includes ceftazidime either alone or in combination with co-trimoxazole. The clinical advantage in adding co-trimoxazole has never been determined; nor has the activity of newer, fourth-generation cephalosporins, such as cefepime, been studied in the treatment of this condition. BALB/c mice have been shown to represent an animal model of melioidosis. This animal model was ...
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    Melioidosis is caused by the Gram-negative bacillus Burkholderia pseudomallei. Most clinical reports of disease are from south-east Asia and northern Australia. The organism is intrinsically resistant to most commonly available antibiotics. Standard therapy includes ceftazidime either alone or in combination with co-trimoxazole. The clinical advantage in adding co-trimoxazole has never been determined; nor has the activity of newer, fourth-generation cephalosporins, such as cefepime, been studied in the treatment of this condition. BALB/c mice have been shown to represent an animal model of melioidosis. This animal model was used in this study to compare the efficacy of ceftazidime and cefepime alone or with co-trimoxazole, in the therapy of melioidosis. Antibiotic levels in the mice were determined by HPLC, and dosing was modified to keep plasma antibiotic levels at or above the MIC for the organism-antibiotic combination for a significant part of a 12 h period. Bacterial load, as determined by splenic counts, showed that ceftazidime in combination with co-trimoxazole was the most effective therapeutic option. The animal model described in this study can be used as a preliminary evaluation of therapeutic options for melioidosis.
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    Journal Title
    Journal of Antimicrobial Chemotherapy
    Volume
    51
    Issue
    1
    Publisher URI
    http://jac.oxfordjournals.org/
    DOI
    https://doi.org/10.1093/jac/dkg011
    Copyright Statement
    © 2003 Oxford University Press. Please refer to the link for the definitive publisher-authenticated version. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review.
    Subject
    Microbiology
    Medical microbiology
    Medical bacteriology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/25825
    Collection
    • Journal articles

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