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dc.contributor.authorN. Peart, Jasonen_US
dc.contributor.authorR. Gross, Ericen_US
dc.contributor.authorJ. Gross, Garretten_US
dc.date.accessioned2017-05-03T13:03:44Z
dc.date.available2017-05-03T13:03:44Z
dc.date.issued2005en_US
dc.date.modified2009-09-28T06:51:13Z
dc.identifier.issn15371891en_US
dc.identifier.doi10.1016/j.vph.2005.02.003en_AU
dc.identifier.urihttp://hdl.handle.net/10072/25828
dc.description.abstractOpioids, named by Acheson [Martin, W.R., 1967. Opioid antagonists.Pharmacol Rev. 19, 463-521] for compounds with morphine-like actions despite chemically distinct structures, have received much research interest, particularly for their central nervous system (CNS) actions involved in pain management, resulting in thousands of scientific papers focusing on their effects on the CNS and other organ systems. A more recent area which may have great clinical importance concerns the role of opioids, either endogenous or exogenous compounds, in limiting the pathogenesis of ischemia-reperfusion injury in heart and brain. The role of endogenous opioids in hibernation provides tantalizing evidence for the protective potential of opioids against ischemia or hypoxia. Mammalian hibernation, a distinct energy-conserving state, is associated with depletion of energy stores, intracellular acidosis and hypoxia, similar to those which occur during ischemia. However, despite the potentially detrimental cellular state induced with hibernation, the myocardium remains resilient for many months. What accounts for the hypoxia-tolerant state is of great interest. During hibernation, circulating levels of opioid peptides are increased dramatically, and indeed, are considered a "trigger" of hibernation. Furthermore, administration of opioid antagonists can effectively reverse hibernation in mammals. Therefore, it is not surprising that activation of opioid receptors has been demonstrated to preserve cellular status following a hypoxic insult, such as ischemia-reperfusion in many model systems including the intestine [Zhang, Y., Wu, Y.X., Hao, Y.B., Dun, Y., Yang, S.P., 2001. Role of endogenous opioid peptides in protection of ischemic preconditioning in rat small intestine. Life Sci. 68, 1013-1019], skeletal muscle [Addison, P.D., Neligan, P.C., Ashrafpour, H., Khan, A., Zhong, A., Moses, M., Forrest, C.R., Pang, C.Y., 2003. Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction. Am. J. Physiol. Heart Circ. Physiol. 285, H1435-H1443], the CNS [Borlongan, C.V., Wang, Y., Su, T.P., 2005. Delta opioid peptide (d-ala 2, d-leu 5) enkephalin: linking hibernation and neuroprotection. Front Biosci. 9, 3392-3398] and the myocardium Romano et al., 2004 and Peart and Gross, 2004a. For the purpose of this review, we will focus primarily on the protective effects of opioids against post-reperfusion myocardial stunning and infarction.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Inc.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom211en_US
dc.relation.ispartofpageto218en_US
dc.relation.ispartofissue5-6en_US
dc.relation.ispartofjournalVascular Pharmacologyen_US
dc.relation.ispartofvolume42en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode320503en_US
dc.titleOpioid-induced preconditioning: recent advances and future perspectivesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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