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  • BALB/c and C57Bl/6 mice infected with virulentBurkholderia pseudomalleiprovide contrasting animal models for the acute and chronic forms of human melioidosis

    Author(s)
    Leakey, AK
    Ulett, GC
    Hirst, RG
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    1998
    Metadata
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    Abstract
    Burkholderia pseudomallei is the aetiological agent of melioidosis, a life-threatening bacterial disease occurring in many species of animals, including man. Infection in humans commonly manifests as one of three clinical presentations: acute, subacute or chronic disease. Investigations were undertaken to assess the suitability of BALB/c and C57Bl/6 mice as animal models for the different forms of human melioidosis. The course of infection in BALB/c mice was similar to that which occurs in acute human infection. By contrast, infection of C57Bl/6 mice appeared to mimic chronic human melioidosis. While BALB/c mice suffered a ...
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    Burkholderia pseudomallei is the aetiological agent of melioidosis, a life-threatening bacterial disease occurring in many species of animals, including man. Infection in humans commonly manifests as one of three clinical presentations: acute, subacute or chronic disease. Investigations were undertaken to assess the suitability of BALB/c and C57Bl/6 mice as animal models for the different forms of human melioidosis. The course of infection in BALB/c mice was similar to that which occurs in acute human infection. By contrast, infection of C57Bl/6 mice appeared to mimic chronic human melioidosis. While BALB/c mice suffered a rapidly-progressive bacteraemia which resulted in host death by 96 h, C57Bl/6 mice were able to prevent this, and typically remained asymptomatic for up to 6 weeks. LD50 values of 4 cells and 2.5䱰4 cells for BALB/c and C57Bl/6 mice, respectively, reflect these observations. The heightened level of resistance to B. pseudomallei observed in C57Bl/6 mice was suggested to have a genetic basis, when the susceptibilities of first filial and reciprocal backcross generations were examined. Growth kinetics of B. pseudomallei within BALB/c and C57Bl/6 peritoneal exudate cell (PEC) cultures were examined to investigate PEC microbicidal efficiency as a determinant of host susceptibility. C57Bl/6 PEC cultures exhibited greater microbicidal efficiency towards B. pseudomallei when compared to BALB/c cells, indicating that susceptibility may be determined by non-specific, cellular mechanisms. Collectively, these results suggest that the BALB/c and C57Bl/6 strains of mice may provide excellent models for acute and chronic human melioidosis, respectively.
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    Journal Title
    Microbial Pathogenesis
    Volume
    24
    Issue
    5
    Publisher URI
    http://www.sciencedirect.com/science/journal/08824010
    DOI
    https://doi.org/10.1006/mpat.1997.0179
    Copyright Statement
    © 1998 Elsevier. Please refer to the journal's website for access to the definitive, published version.This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher.
    Subject
    Microbiology
    Immunology
    Medical microbiology
    Medical bacteriology
    Publication URI
    http://hdl.handle.net/10072/25832
    Collection
    • Journal articles

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