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dc.contributor.authorKetheesan, N
dc.contributor.authorBarnes, JL
dc.contributor.authorUlett, GC
dc.contributor.authorVanGessel, HJ
dc.contributor.authorNorton, RE
dc.contributor.authorHirst, RG
dc.contributor.authorLaBrooy, JT
dc.date.accessioned2017-05-03T15:29:25Z
dc.date.available2017-05-03T15:29:25Z
dc.date.issued2002
dc.date.modified2009-09-29T23:13:51Z
dc.identifier.issn0022-1899
dc.identifier.doi10.1086/341222
dc.identifier.urihttp://hdl.handle.net/10072/25834
dc.description.abstractMelioidosis is a bacterial infection caused by Burkholderia pseudomallei. The aim of this study was to determine whether a cell-mediated adaptive immune response against B. pseudomallei developed in patients who had recovered from melioidosis. Lymphocyte proliferation assays were done on peripheral blood mononuclear cells from patients (n=13) and control subjects (n=10) to determine the lymphocyte response to B. pseudomallei antigens. Production of interferon-g and interleukin-10 was also determined. Activation of T cell subsets was assessed by fluorescence-activated cell sorter analysis, using antibodies to CD4, CD8, and CD69 antigens. Lymphocyte proliferation and interferon-g production in response to B. pseudomallei antigens were significantly higher (P= .001 for both) in patients than in control subjects. There was also an increase in the percentage of activated CD4+ (P= .004) and activated CD8+ T cells (P= .035) in cell cultures from patients. The development of such a cellmediated immune response in patients may be essential for their survival.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent78289 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherUniversity of Chicago
dc.publisher.placeUSA
dc.publisher.urihttps://academic.oup.com/jid/article/186/2/286/835981?searchresult=1
dc.relation.ispartofpagefrom286
dc.relation.ispartofpageto289
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume186
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320701
dc.titleDemonstration of a Cell-Mediated Immune Response in Melioidosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2002 by University of Chicago Press. First published in Journal of Infectious Diseases with publishing partner University of Chicago. Use hypertext link to access the journal's webpage. The attached file is reproduced here in accordance with the copyright policy of the publisher.
gro.date.issued2002
gro.hasfulltextFull Text
gro.griffith.authorUlett, Glen C.


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