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  • Mechanisms of Group B Streptococcal-Induced Apoptosis of Murine Macrophages

    Author(s)
    Ulett, GC
    Maclean, KH
    Nekkalapu, S
    Cleveland, JL
    Adderson, EE
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    2005
    Metadata
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    Abstract
    Apoptosis of murine and human macrophages induced by group B Streptococcus agalactiae (GBS) is likely an important virulence mechanism that is used by the bacteria to suppress the host immune response and to persist at sites of infection. The mechanisms by which GBS induces apoptosis are, however, largely unknown. In this study, we report that in murine macrophages GBS induces unique changes in the regulation and localization of the apoptotic regulators Bad, 14-3-3, and Omi/high-temperature requirement A2 and leads to the release of cytochrome c and the activation of caspase-9 and caspase-3. Furthermore, inhibition of caspase-3 ...
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    Apoptosis of murine and human macrophages induced by group B Streptococcus agalactiae (GBS) is likely an important virulence mechanism that is used by the bacteria to suppress the host immune response and to persist at sites of infection. The mechanisms by which GBS induces apoptosis are, however, largely unknown. In this study, we report that in murine macrophages GBS induces unique changes in the regulation and localization of the apoptotic regulators Bad, 14-3-3, and Omi/high-temperature requirement A2 and leads to the release of cytochrome c and the activation of caspase-9 and caspase-3. Furthermore, inhibition of caspase-3 impaired GBS-induced apoptosis of macrophages. The ability to modulate the activity of effector caspases may therefore represent an unexploited avenue for therapeutic intervention in GBS infections.
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    Journal Title
    Journal of Immunology
    Volume
    175
    Issue
    4
    Publisher URI
    http://www.jimmunol.org/
    Subject
    Immunology
    Medical bacteriology
    Publication URI
    http://hdl.handle.net/10072/25837
    Collection
    • Journal articles

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