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  • Macrophage-Lymphocyte Interactions Mediate Anti-Burkholderia pseudomallei Activity

    Author(s)
    Ulett, GC
    Ketheesan, N
    Hirst, RG
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    1998
    Metadata
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    Abstract
    The mechanisms involved in the pathogenesis of melioidosis, caused by the intracellular bacterium Burkholderia pseudomallei, are unclear. C57BL/6 mice are resistant to infection, while BALB/c mice are highly susceptible. Previous studies have demonstrated that peritoneal exudate cell preparations enriched for macrophages are capable of effectively eliminating intracellular pathogens. In this study we present evidence showing that interaction of macrophages with lymphocytes is necessary for efficient anti-B. pseudomallei activity.The mechanisms involved in the pathogenesis of melioidosis, caused by the intracellular bacterium Burkholderia pseudomallei, are unclear. C57BL/6 mice are resistant to infection, while BALB/c mice are highly susceptible. Previous studies have demonstrated that peritoneal exudate cell preparations enriched for macrophages are capable of effectively eliminating intracellular pathogens. In this study we present evidence showing that interaction of macrophages with lymphocytes is necessary for efficient anti-B. pseudomallei activity.
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    Journal Title
    FEMS Immunology & Medical Microbiology
    Volume
    21
    Issue
    4
    Publisher URI
    https://www.sciencedirect.com/science/article/pii/S0928824498000820
    DOI
    https://doi.org/10.1111/j.1574-695X.1998.tb01175.x
    Subject
    Cardiovascular medicine and haematology
    Immunology
    Medical microbiology
    Medical bacteriology
    Publication URI
    http://hdl.handle.net/10072/25843
    Collection
    • Journal articles

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