Macrophage-Lymphocyte Interactions Mediate Anti-Burkholderia pseudomallei Activity
Author(s)
Ulett, GC
Ketheesan, N
Hirst, RG
Griffith University Author(s)
Year published
1998
Metadata
Show full item recordAbstract
The mechanisms involved in the pathogenesis of melioidosis, caused by the intracellular bacterium Burkholderia pseudomallei, are unclear. C57BL/6 mice are resistant to infection, while BALB/c mice are highly susceptible. Previous studies have demonstrated that peritoneal exudate cell preparations enriched for macrophages are capable of effectively eliminating intracellular pathogens. In this study we present evidence showing that interaction of macrophages with lymphocytes is necessary for efficient anti-B. pseudomallei activity.The mechanisms involved in the pathogenesis of melioidosis, caused by the intracellular bacterium Burkholderia pseudomallei, are unclear. C57BL/6 mice are resistant to infection, while BALB/c mice are highly susceptible. Previous studies have demonstrated that peritoneal exudate cell preparations enriched for macrophages are capable of effectively eliminating intracellular pathogens. In this study we present evidence showing that interaction of macrophages with lymphocytes is necessary for efficient anti-B. pseudomallei activity.
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Journal Title
FEMS Immunology & Medical Microbiology
Volume
21
Issue
4
Subject
Cardiovascular medicine and haematology
Immunology
Medical microbiology
Medical bacteriology