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  • G-CSF Immunotherapy for Treatment of Acute Disseminated Murine Melioidosis

    Author(s)
    Powell, K
    Ulett, G
    Hirst, R
    Norton, R
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    2003
    Metadata
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    Abstract
    Burkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in tropical regions of Australia and Southeast Asia. Antibiotic therapy can be ineffective in patients with acute septicaemic melioidosis. It has been proposed that adjunctive immunotherapy using granulocyte colony stimulating factor (G-CSF) combined with antibiotics may provide an alternative approach to antibiotics alone. We have developed a murine model for melioidosis that allows novel treatment approaches to be investigated. This study looked at the potential for murine G-CSF therapy both alone and as an adjunct in the treatment of ...
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    Burkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in tropical regions of Australia and Southeast Asia. Antibiotic therapy can be ineffective in patients with acute septicaemic melioidosis. It has been proposed that adjunctive immunotherapy using granulocyte colony stimulating factor (G-CSF) combined with antibiotics may provide an alternative approach to antibiotics alone. We have developed a murine model for melioidosis that allows novel treatment approaches to be investigated. This study looked at the potential for murine G-CSF therapy both alone and as an adjunct in the treatment of acute disseminated B. pseudomallei infection in BALB/c mice. A number of therapeutic variables involving ceftazidime and recombinant murine G-CSF were studied. Surviving mice were sacrificed and splenic bacterial loads were determined. Combining recombinant murine G-CSF with ceftazidime offered no advantage over ceftazidime alone. Pre-treatment with recombinant murine G-CSF did not demonstrate a significant benefit. This would suggest that adjunct immunotherapy using G-CSF is of limited benefit.
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    Journal Title
    FEMS Microbiology Letters
    Volume
    224
    Issue
    2
    Publisher URI
    http://www.sciencedirect.com/science/journal/03781097
    DOI
    https://doi.org/10.1016/S0378-1097(03)00473-7
    Copyright Statement
    © 2003 Wiley-Blackwell Publishing. The definitive version is available at www.interscience.wiley.com This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.
    Subject
    Biological sciences
    Agricultural, veterinary and food sciences
    Biomedical and clinical sciences
    Medical bacteriology
    Publication URI
    http://hdl.handle.net/10072/25845
    Collection
    • Journal articles

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