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dc.contributor.authorPowell, Kellieen_US
dc.contributor.authorUlett, Glenen_US
dc.contributor.authorHirst, Roberten_US
dc.contributor.authorNorton, Roberten_US
dc.date.accessioned2017-04-24T13:03:28Z
dc.date.available2017-04-24T13:03:28Z
dc.date.issued2003en_US
dc.date.modified2009-09-29T23:14:44Z
dc.identifier.issn03781097en_US
dc.identifier.doi10.1016/S0378-1097(03)00473-7en_AU
dc.identifier.urihttp://hdl.handle.net/10072/25845
dc.description.abstractBurkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in tropical regions of Australia and Southeast Asia. Antibiotic therapy can be ineffective in patients with acute septicaemic melioidosis. It has been proposed that adjunctive immunotherapy using granulocyte colony stimulating factor (G-CSF) combined with antibiotics may provide an alternative approach to antibiotics alone. We have developed a murine model for melioidosis that allows novel treatment approaches to be investigated. This study looked at the potential for murine G-CSF therapy both alone and as an adjunct in the treatment of acute disseminated B. pseudomallei infection in BALB/c mice. A number of therapeutic variables involving ceftazidime and recombinant murine G-CSF were studied. Surviving mice were sacrificed and splenic bacterial loads were determined. Combining recombinant murine G-CSF with ceftazidime offered no advantage over ceftazidime alone. Pre-treatment with recombinant murine G-CSF did not demonstrate a significant benefit. This would suggest that adjunct immunotherapy using G-CSF is of limited benefit.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBlackwell Publishing Ltden_US
dc.publisher.placeThe Netherlandsen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/03781097en_AU
dc.relation.ispartofpagefrom315en_US
dc.relation.ispartofpageto318en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalFEMS Microbiology Lettersen_US
dc.relation.ispartofvolume224en_US
dc.subject.fieldofresearchMedical Bacteriologyen_US
dc.subject.fieldofresearchcode110801en_US
dc.titleG-CSF Immunotherapy for Treatment of Acute Disseminated Murine Melioidosisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2003 Wiley-Blackwell Publishing. The definitive version is available at www.interscience.wiley.com This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.en_AU
gro.date.issued2003
gro.hasfulltextNo Full Text


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