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  • β-Hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus

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    2003_GCU_JID_PP.pdf (290.7Kb)
    Author(s)
    Ulett, GC
    Bohnsack, JF
    Armstrong, J
    Adderson, EE
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    2003
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    Abstract
    Group B streptococcus (GBS) induces apoptosis in macrophages. Growth conditions minimizing b-hemolysin expression, such as high glucose, reduce apoptosis. We constructed an isogenic mutant strain of GBS 874391 lacking the b-hemolysin structural gene cylE and investigated the role that bhemolysin plays in apoptosis of J774 macrophages. Viability of macrophages infected with wild-type or cylE GBS was similar and significantly less than that of macrophages infected with GBS grown in high-glucose media. Thus, apoptosis in GBS-infected macrophages is dependent not on b-hemolysin but on a factor coregulated with b-hemolysin by glucose.Group B streptococcus (GBS) induces apoptosis in macrophages. Growth conditions minimizing b-hemolysin expression, such as high glucose, reduce apoptosis. We constructed an isogenic mutant strain of GBS 874391 lacking the b-hemolysin structural gene cylE and investigated the role that bhemolysin plays in apoptosis of J774 macrophages. Viability of macrophages infected with wild-type or cylE GBS was similar and significantly less than that of macrophages infected with GBS grown in high-glucose media. Thus, apoptosis in GBS-infected macrophages is dependent not on b-hemolysin but on a factor coregulated with b-hemolysin by glucose.
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    Journal Title
    Journal of Infectious Diseases
    Volume
    188
    Issue
    7
    Publisher URI
    https://academic.oup.com/jid/article/188/7/1049/818964
    DOI
    https://doi.org/10.1086/378202
    Copyright Statement
    © 2003 by University of Chicago Press. First published in Journal of Infectious Diseaseswith publishing partner University of Chicago. Use hypertext link to access the journal's webpage. The attached file is reproduced here in accordance with the copyright policy of the publisher.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Medical bacteriology
    Publication URI
    http://hdl.handle.net/10072/25846
    Collection
    • Journal articles

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