β-Hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus
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Group B streptococcus (GBS) induces apoptosis in macrophages. Growth conditions minimizing b-hemolysin expression, such as high glucose, reduce apoptosis. We constructed an isogenic mutant strain of GBS 874391 lacking the b-hemolysin structural gene cylE and investigated the role that bhemolysin plays in apoptosis of J774 macrophages. Viability of macrophages infected with wild-type or cylE GBS was similar and significantly less than that of macrophages infected with GBS grown in high-glucose media. Thus, apoptosis in GBS-infected macrophages is dependent not on b-hemolysin but on a factor coregulated with b-hemolysin by glucose.
Journal of Infectious Diseases
© 2003 by University of Chicago Press. First published in Journal of Infectious Diseaseswith publishing partner University of Chicago. Use hypertext link to access the journal's webpage. The attached file is reproduced here in accordance with the copyright policy of the publisher.