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  • Colonisation dynamics and virulence of two clonal groups of multidrug-resistant Escherichia coli isolated from dogs

    Author(s)
    Sidjabat, Hanna E
    Chin, James J-C
    Chapman, Toni
    Wu, Kent
    Ulett, Glen C
    Ong, Cheryl Y
    Schembri, Mark A
    Johnson, James R
    Trott, Darren J
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    2009
    Metadata
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    Abstract
    The study established the virulence potential of multidrug-resistant Escherichia coli (MDREC) isolates from nosocomial infections in hospitalised dogs. The isolates were resistant to fluoroquinolones, belonged to two distinct clonal groups (CG1 and CG2) and contained a plasmid-mediated AmpC (CMY-7) ߭lactamase. CG1 isolates (n = 14) possessed two of 36 assayed extraintestinal virulence genes (iutA and traT) and belonged to phylogenetic group A, whereas CG2 isolates (n = 19) contained four such genes (iutA, ibeA, fimH and kpsMT K5) and belonged to group D. In a mouse gastrointestinal tract colonisation model, colonisation by ...
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    The study established the virulence potential of multidrug-resistant Escherichia coli (MDREC) isolates from nosocomial infections in hospitalised dogs. The isolates were resistant to fluoroquinolones, belonged to two distinct clonal groups (CG1 and CG2) and contained a plasmid-mediated AmpC (CMY-7) ߭lactamase. CG1 isolates (n = 14) possessed two of 36 assayed extraintestinal virulence genes (iutA and traT) and belonged to phylogenetic group A, whereas CG2 isolates (n = 19) contained four such genes (iutA, ibeA, fimH and kpsMT K5) and belonged to group D. In a mouse gastrointestinal tract colonisation model, colonisation by index CG1 strain C1 was transient, in contrast to the index CG2 strain C2b, which persisted up to 40 days post-inoculation. In a mouse subcutaneous challenge model, both strains were less virulent than archetypal group B2 extraintestinal pathogenic E. coli (ExPEC) strain CFT073; strain C1 caused no systemic signs and strain C2b was lethal to only one of six mice. In a mouse urinary tract infection model, strain C2b colonised the mouse bladder over 2 logs higher compared to strain C1. Whilst both groups of canine MDREC appear less virulent than a reference human ExPEC strain, CG2 strains have greater capacity for colonisation and virulence.
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    Journal Title
    Microbes and Infection
    Volume
    11
    Issue
    1
    Publisher URI
    http://www.sciencedirect.com/science/journal/12864579
    DOI
    https://doi.org/10.1016/j.micinf.2008.10.014
    Subject
    Microbiology
    Bacteriology
    Infectious agents
    Immunology
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/25866
    Collection
    • Journal articles

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