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  • Acute adenosinergic cardioprotection in ischemic-reperfused hearts

    Author(s)
    Headrick, JP
    Hack, B
    Ashton, KJ
    Griffith University Author(s)
    Headrick, John P.
    Year published
    2003
    Metadata
    Show full item record
    Abstract
    Cells of the cardiovascular system generate and release purine nucleoside adenosine in increasing quantities when constituent cells are "stressed" or subjected to injurious stimuli. This increased adenosine can interact with surface receptors in myocardial, vascular, fibroblast, and inflammatory cells to modulate cellular function and phenotype. Additionally, adenosine is rapidly reincorporated back into 5'-AMP to maintain the adenine nucleotide pool. Via these receptor-dependent and independent (metabolic) paths, adenosine can substantially modify the acute response to ischemic insult, in addition to generating a more ...
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    Cells of the cardiovascular system generate and release purine nucleoside adenosine in increasing quantities when constituent cells are "stressed" or subjected to injurious stimuli. This increased adenosine can interact with surface receptors in myocardial, vascular, fibroblast, and inflammatory cells to modulate cellular function and phenotype. Additionally, adenosine is rapidly reincorporated back into 5'-AMP to maintain the adenine nucleotide pool. Via these receptor-dependent and independent (metabolic) paths, adenosine can substantially modify the acute response to ischemic insult, in addition to generating a more sustained ischemia-tolerant phenotype (preconditioning). However, the molecular basis for acute adenosinergic cardioprotection remains incompletely understood and may well differ from more widely studied preconditioning. Here we review current knowledge and some controversies regarding acute cardioprotection via adenosine and adenosine receptor activation.
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    Journal Title
    American Journal of Physiology: Heart and Circulatory Physiology
    Volume
    285
    Publisher URI
    http://ajpheart.physiology.org/content/285/5/H1797
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Zoology
    Medical physiology
    Cardiovascular medicine and haematology
    Publication URI
    http://hdl.handle.net/10072/25867
    Collection
    • Journal articles

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