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dc.contributor.authorHeadrick, Johnen_US
dc.contributor.authorHack, Benjaminen_US
dc.contributor.authorAshton, Kevinen_US
dc.date.accessioned2017-04-24T08:09:02Z
dc.date.available2017-04-24T08:09:02Z
dc.date.issued2003en_US
dc.identifier.issn03636135en_US
dc.identifier.urihttp://hdl.handle.net/10072/25867
dc.description.abstractCells of the cardiovascular system generate and release purine nucleoside adenosine in increasing quantities when constituent cells are "stressed" or subjected to injurious stimuli. This increased adenosine can interact with surface receptors in myocardial, vascular, fibroblast, and inflammatory cells to modulate cellular function and phenotype. Additionally, adenosine is rapidly reincorporated back into 5'-AMP to maintain the adenine nucleotide pool. Via these receptor-dependent and independent (metabolic) paths, adenosine can substantially modify the acute response to ischemic insult, in addition to generating a more sustained ischemia-tolerant phenotype (preconditioning). However, the molecular basis for acute adenosinergic cardioprotection remains incompletely understood and may well differ from more widely studied preconditioning. Here we review current knowledge and some controversies regarding acute cardioprotection via adenosine and adenosine receptor activation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAmerican Physiological Societyen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://ajpheart.physiology.org/content/285/5/H1797en_US
dc.relation.ispartofpagefromH1797en_US
dc.relation.ispartofpagetoH1819en_US
dc.relation.ispartofjournalAmerican Journal of Physiology: Heart and Circulatory Physiologyen_US
dc.relation.ispartofvolume285en_US
dc.subject.fieldofresearchcode321003en_US
dc.titleAcute adenosinergic cardioprotection in ischemic-reperfused heartsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_US
gro.date.issued2015-02-05T03:43:28Z
gro.hasfulltextNo Full Text


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