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  • Virulence properties of asymptomatic bacteriuria Escherichia coli

    Author(s)
    Mabbett, Amanda N
    Ulett, Glen C
    Watts, Rebecca E
    Tree, Jai J
    Totsika, Makrina
    Ong, Cheryl-lynn Y
    Wood, Jacqueline M
    Monaghan, Wayne
    Looke, David F
    Nimmo, Graeme R
    Svanborg, Catharina
    Schembri, Mark A
    Griffith University Author(s)
    Ulett, Glen C.
    Year published
    2009
    Metadata
    Show full item record
    Abstract
    In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were ...
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    In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E. coli evade immune detection after the establishment of bacteriuria.
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    Journal Title
    International Journal of Medical Microbiology
    Volume
    299
    Issue
    1
    Publisher URI
    http://www.sciencedirect.com/science/journal/14384221
    DOI
    https://doi.org/10.1016/j.ijmm.2008.06.003
    Subject
    Innate immunity
    Medical microbiology
    Medical bacteriology
    Publication URI
    http://hdl.handle.net/10072/25872
    Collection
    • Journal articles

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