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dc.contributor.authorMabbett, Amanda N
dc.contributor.authorUlett, Glen C
dc.contributor.authorWatts, Rebecca E
dc.contributor.authorTree, Jai J
dc.contributor.authorTotsika, Makrina
dc.contributor.authorOng, Cheryl-lynn Y
dc.contributor.authorWood, Jacqueline M
dc.contributor.authorMonaghan, Wayne
dc.contributor.authorLooke, David F
dc.contributor.authorNimmo, Graeme R
dc.contributor.authorSvanborg, Catharina
dc.contributor.authorSchembri, Mark A
dc.date.accessioned2017-05-03T15:29:31Z
dc.date.available2017-05-03T15:29:31Z
dc.date.issued2009
dc.date.modified2009-12-01T05:31:32Z
dc.identifier.issn1438-4221
dc.identifier.doi10.1016/j.ijmm.2008.06.003
dc.identifier.urihttp://hdl.handle.net/10072/25872
dc.description.abstractIn asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E. coli evade immune detection after the establishment of bacteriuria.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherUrban and Fischer
dc.publisher.placeGermany
dc.publisher.urihttp://www.sciencedirect.com/science/journal/14384221
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom53
dc.relation.ispartofpageto63
dc.relation.ispartofissue1
dc.relation.ispartofjournalInternational Journal of Medical Microbiology
dc.relation.ispartofvolume299
dc.rights.retentionY
dc.subject.fieldofresearchInnate immunity
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode320407
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode320701
dc.titleVirulence properties of asymptomatic bacteriuria Escherichia coli
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorUlett, Glen C.
gro.griffith.authorNimmo, Graeme R.


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