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dc.contributor.authorTree, Jai J
dc.contributor.authorUlett, Glen C
dc.contributor.authorOng, Cheryl-Lynn Y
dc.contributor.authorTrott, Darren J
dc.contributor.authorMcEwan, Alastair G
dc.contributor.authorSchembri, Mark A
dc.date.accessioned2017-09-05T01:46:16Z
dc.date.available2017-09-05T01:46:16Z
dc.date.issued2008
dc.date.modified2009-09-29T23:14:07Z
dc.identifier.issn0021-9193
dc.identifier.doi10.1128/JB.00451-08
dc.identifier.urihttp://hdl.handle.net/10072/25873
dc.description.abstractThe periplasmic multicopper oxidase (CueO) is involved in copper homeostasis and protection against oxidative stress. Here, we show that the deletion of cueO in uropathogenic Escherichia coli increases its colonization of the urinary tract despite its increased sensitivity to hydrogen peroxide. The cueO deletion mutant accumulated iron with increased efficiency compared to its parent strain; this may account for its advantage in the iron-limited environment of the urinary tract.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUSA
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom6909
dc.relation.ispartofpageto6912
dc.relation.ispartofissue20
dc.relation.ispartofjournalJournal of Bacteriology
dc.relation.ispartofvolume190
dc.rights.retentionY
dc.subject.fieldofresearchMedical Bacteriology
dc.subject.fieldofresearchMedical Microbiology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110801
dc.subject.fieldofresearchcode110899
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleTrade-off between iron uptake and protection against oxidative stress: deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPublished
gro.rights.copyright© 2008 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2008
gro.hasfulltextFull Text
gro.griffith.authorUlett, Glen C.


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