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dc.contributor.authorHenderson, Ginnyen_US
dc.contributor.authorCraig, S.en_US
dc.contributor.authorBrocklehurst, P.en_US
dc.contributor.authorMcGuire, W.en_US
dc.date.accessioned2017-05-03T15:14:56Z
dc.date.available2017-05-03T15:14:56Z
dc.date.issued2009en_US
dc.date.modified2010-01-12T06:53:36Z
dc.identifier.issn13592998en_US
dc.identifier.doi10.1136/adc.2007.119560en_AU
dc.identifier.urihttp://hdl.handle.net/10072/26061
dc.description.abstractBackground: Most preterm infants who develop necrotising enterocolitis (NEC) have received enteral feeds. Uncertainty exists about which aspects of the feeding regimen affect the risk of NEC. Aim: To examine associations between enteral feeding practices and the development NEC in preterm infants. Methods: Multi-centre case-control study. 53 preterm infants with NEC were enrolled together with gestational-age frequency-matched control infants without NEC from a randomly selected neonatal unit. Clinical and feeding data were extracted and compared between the groups. Results: Significantly fewer cases than controls had received human breast milk [75% versus 91%: odds ratio= 0.32 (95% confidence interval (CI) 0.11 to 0.98)]. The day after birth on which enteral feeding was commenced did not differ significantly: mean cases 2.9 (standard deviation [SD] 2.8); controls 2.8 (SD 1.8). The mean duration of trophic feeding (<1mL/kg/h) was significantly shorter in the cases [3.3 (SD 3.1) days] than controls [6.2 (SD 6.7) days]: mean difference [MD] 2.9 (95% CI 4.9 to 0.9) days. Cases were fully fed significantly earlier than controls [cases 9.9 (SD 4.2); controls 14.3 (SD 9.8): MD 4.4 (95% CI 7.3 to 1.5) days after birth]. Conclusions: This study found that the duration of trophic feeding and rate of advancement of feed volumes was associated with the risk of NEC in preterm infants. Further randomised controlled trials that assess the effect of different rates of feed advancement on the incidence of NEC, as well as other outcomes, are warranted.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent123385 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBMJ Publishinhg Group Ltden_US
dc.publisher.placeLondonen_US
dc.publisher.urihttp://adc.bmj.com/en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefromF120en_US
dc.relation.ispartofpagetoF123en_US
dc.relation.ispartofjournalArchives of Disease in Childhood. Fetal and Neonatal Editionen_US
dc.relation.ispartofvolume94en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode321199en_US
dc.titleEnteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case-control studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Nursing and Midwiferyen_US
gro.rights.copyrightCopyright remains with the authors 2009 . This file is posted here with permission of the copyright owner for your personal use only. No further distribution permitted. For information about this journal please refer to the publisher's website or contact the authors.en_AU
gro.date.issued2009
gro.hasfulltextFull Text


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