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dc.contributor.authorHenderson, Ginnyen_US
dc.contributor.authorCraig, Sen_US
dc.contributor.authorBaier, RJen_US
dc.contributor.authorHelps, Nen_US
dc.contributor.authorBrocklehurst, Pen_US
dc.contributor.authorMcGuire, Men_US
dc.date.accessioned2017-04-24T12:45:26Z
dc.date.available2017-04-24T12:45:26Z
dc.date.issued2009en_US
dc.date.modified2010-01-12T06:54:32Z
dc.identifier.issn13592998en_US
dc.identifier.doi10.1136/adc.2007.119933en_AU
dc.identifier.urihttp://hdl.handle.net/10072/26065
dc.description.abstractBackground: The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease process.Aim: To examine associations between the common genetic variants in candidate inflammatory cytokine genes and NEC in preterm infants.Methods: Multi-centre case-control and genetic association study. We collected DNA samples from 50 preterm infants with NEC and 50 gestational age and ethnic group frequency-matched controls recruited to a multi-centre case-control study. We genotyped 10 candidate single nucleotide polymorphisms (SNPs) in cytokines previously associated with infectious or inflammatory diseases in preterm infants. The findings were included in random effects meta-analyses with data from previous genetic association studies.Results: All allele distributions were in Hardy-Weinberg equilibrium. None of the studied cytokine polymorphisms was significantly associated with NEC. We found four previous genetic association studies of cytokine polymorphisms and NEC in preterm infants. Meta-analyses were possible for several SNPs. These increased the precision of the estimates of effect size but did not reveal any significant associations.Conclusions: The available data are not consistent with more than modest associations between these candidate cytokine variant alleles and NEC in preterm infants. Data from future association studies of these polymorphisms may be added to the meta-analyses to obtain more precise estimates of effects sizes.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent285981 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBMJ Publishinhg Group Ltden_US
dc.publisher.placeLondonen_US
dc.publisher.urihttp://www.bmj.com/en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefromF124en_US
dc.relation.ispartofpagetoF128en_US
dc.relation.ispartofjournalArchives of Disease in Childhood - Fetal and Neonatal Editionen_US
dc.relation.ispartofvolume94en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode321199en_US
dc.titleCytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Nursing and Midwiferyen_US
gro.rights.copyrightCopyright remains with the authors 2009 . This attached file is posted here with permission of the copyright owner for your personal use only. No further distribution permitted. For information about this journal please refer to the publisher's website or contact the authors.en_AU
gro.date.issued2009
gro.hasfulltextFull Text


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