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  • Progression of periodontal disease and interleukin-10 gene polymorphism

    Author(s)
    Cullinan, MP
    Westerman, B
    Hamlet, SM
    Palmer, JE
    Faddy, MJ
    Seymour, GJ
    Middleton, PG
    Taylor, JJ
    Griffith University Author(s)
    Hamlet, Stephen
    Year published
    2008
    Metadata
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    Abstract
    Background and Objective: Interleukin-10 is a key immunoregulatory cytokine that may be of significance in the immunopathogenesis of chronic inflammatory diseases such as periodontal disease. Molecular genetic studies have defined a number of haplotypes that may be associated with differing levels of interleukin-10 secretion. The present study investigated the possible association between interleukin-10 gene polymorphism and periodontal disease progression. Material and Methods: Genomic DNA was obtained from 252 adults who were part of a prospective longitudinal study on the progression of periodontal disease in a ...
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    Background and Objective: Interleukin-10 is a key immunoregulatory cytokine that may be of significance in the immunopathogenesis of chronic inflammatory diseases such as periodontal disease. Molecular genetic studies have defined a number of haplotypes that may be associated with differing levels of interleukin-10 secretion. The present study investigated the possible association between interleukin-10 gene polymorphism and periodontal disease progression. Material and Methods: Genomic DNA was obtained from 252 adults who were part of a prospective longitudinal study on the progression of periodontal disease in a general adult Australian population. Single nucleotide polymorphisms at positions -592 and -1082 in the interleukin-10 promoter were analysed using an induced heteroduplex methodology and used to determine interleukin-10 promoter haplotypes in individual samples. Periodontitis progression was assessed by measuring probing depths and relative attachment levels at regular intervals over a 5-year period. A generalized linear model was used to analyse the data, with age, gender, smoking status, interleukin-1 genotype and Porphyromonas gingivalis included as possible confounders. Results: There was a significant (p 蠰.02) main effect of interleukin-10 haplotypes, with individuals having either the ATA/ACC or the ACC/ACC genotype experiencing around 20% fewer probing depths of = 4 mm compared to individuals with other genotypes. Age and smoking had significant (p < 0.001) additional effects. Conclusion: These data suggest that the interleukin-10 genotype contributes to the progression of periodontal disease.
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    Journal Title
    Journal of Periodontal Research
    Volume
    43
    Publisher URI
    https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0765.2007.01034.x
    DOI
    https://doi.org/10.1111/j.1600-0765.2007.01034.x
    Subject
    Dentistry
    Dentistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/26249
    Collection
    • Journal articles

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