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  • Aberrant trafficking of transmembrane proteins in human disease

    Author
    Cobbold, Christian
    P. Monaco, Anthony
    Sivaprasadarao, Asipu
    Ponnambalam, Sreenivasan
    Year published
    2003
    Metadata
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    Abstract
    Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
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    Journal Title
    Trends in Cell Biology
    Volume
    13
    Issue
    12
    Publisher URI
    http://www.cell.com/trends/cell-biology/home
    DOI
    https://doi.org/10.1016/j.tcb.2003.10.008
    Publication URI
    http://hdl.handle.net/10072/26481
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    • Journal articles

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