Aberrant trafficking of transmembrane proteins in human disease
Author(s)
Cobbold, C
Monaco, AP
Sivaprasadarao, A
Ponnambalam, S
Griffith University Author(s)
Year published
2003
Metadata
Show full item recordAbstract
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
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Journal Title
Trends in Cell Biology
Volume
13
Issue
12
Publisher URI
Subject
Biological sciences
Biomedical and clinical sciences