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dc.contributor.authorSloots, TP
dc.contributor.authorMcErlean, P
dc.contributor.authorSpeicher, DJ
dc.contributor.authorArden, KE
dc.contributor.authorNissen, MD
dc.contributor.authorMackay, IM
dc.date.accessioned2017-05-03T15:01:23Z
dc.date.available2017-05-03T15:01:23Z
dc.date.issued2006
dc.date.modified2009-11-09T06:53:42Z
dc.identifier.issn1386-6532
dc.identifier.doi10.1016/j.jcv.2005.09.008
dc.identifier.urihttp://hdl.handle.net/10072/26529
dc.description.abstractUndiagnosed cases of respiratory tract disease suspected of an infectious aetiology peak during the winter months. Since studies applying molecular diagnostic assays usually report reductions in the number of undiagnosed cases of infectious disease compared to traditional techniques, we applied PCR assays to investigate the role of two recently described viruses, namely human coronavirus (HCoV) HKU1 and human bocavirus (HBoV), in a hospital-based paediatric population. Both viruses were found among Australia children with upper or lower respiratory tract disease during the autumn and winter of 2004, contributing to 21.1% of all microbial diagnoses, with individual incidences of 3.1% (HCoV-HKU1) and 5.6% (HBoV) among 324 specimens. HBoV was found to coincide with another virus in more than half of all instances and displayed a single genetic lineage, whilst HCoV-HKU1 was more likely to occur in the absence of another microbe and strains could be divided into two genetic lineages which we propose be termed HCoV-HKU1 type A and type B. Children under the age of 2 years were most at risk of infection by these viruses which contribute significantly to the microbial burden among patients with respiratory tract disease during the colder months.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeAmsterdam, The Netherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom99
dc.relation.ispartofpageto102
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Clinical Virology
dc.relation.ispartofvolume35
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3207
dc.titleEvidence of human coronavirus HKU1 and human bocavirus in Australian children
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorSpeicher, David J.


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