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dc.contributor.authorSt John, JA
dc.contributor.authorKey, B
dc.contributor.editorWolfgang Meyerhof
dc.date.accessioned2017-05-03T15:26:50Z
dc.date.available2017-05-03T15:26:50Z
dc.date.issued2003
dc.date.modified2009-12-18T06:32:22Z
dc.identifier.issn0379-864X
dc.identifier.doi10.1093/chemse/bjg068
dc.identifier.urihttp://hdl.handle.net/10072/26630
dc.description.abstractDuring development, primary olfactory axons typically grow to their topographically correct target zone without extensive remodelling. Similarly, in adults, new axons arising from the normal turnover of sensory neurons essentially project to their target without error. In the present study we have examined axon targeting in the olfactory pathway following extensive chemical ablation of the olfactory neuroepithelium in the P2-tau:LacZ line of mice. These mice express LacZ in the P2 subpopulation of primary olfactory neurons whose axons target topographically fixed glomeruli on the medial and lateral surfaces of the olfactory bulb. Intraperitoneal injections of dichlobenil selectively destroyed the sensory neuroepithelium of the nasal cavity without direct physical insult to the olfactory neuron pathway. Primary olfactory neurons regenerated and LacZ staining revealed the trajectory of the P2 axons. Rather than project solely to their topographically appropriate glomeruli, the regenerating P2 axons now terminated in numerous inappropriate glomeruli which were widely dispersed over the olfactory bulb. While these errors in targeting were refined over time, there was still considerable mis-targeting after four months of regeneration.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeOxford
dc.publisher.urihttp://chemse.oxfordjournals.org/
dc.relation.ispartofpagefrom773
dc.relation.ispartofpageto779
dc.relation.ispartofissue9
dc.relation.ispartofjournalChemical Senses
dc.relation.ispartofvolume28
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode31
dc.titleAxon Mis-targeting in the Olfactory Bulb During Regeneration of Olfactory Neuroepithelium
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorSt John, James A.


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