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  • Motile Membrane Protrusions Regulate Cell-Cell Adhesion and Migration of Olfactory Ensheathing Glia

    Author(s)
    Windus, Louisa CE
    Claxton, Christina
    Allen, Chelsea L
    Key, Brian
    St John, James A
    Griffith University Author(s)
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2007
    Metadata
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    Abstract
    Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lamellipodial protrusions, termed lamellipodial waves, are integral to OEC migration. Time-lapse imaging of migrating OECs revealed that these highly dynamic waves progress along the shaft of the cells and are crucial for mediating cell-cell adhesion. Without these waves, cell-cell adhesion does not occur and ...
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    Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lamellipodial protrusions, termed lamellipodial waves, are integral to OEC migration. Time-lapse imaging of migrating OECs revealed that these highly dynamic waves progress along the shaft of the cells and are crucial for mediating cell-cell adhesion. Without these waves, cell-cell adhesion does not occur and migrational rates decline. The activity of waves is modulated by both glial cell line-derived neurotrophic factor and inhibitors of the JNK and SRC kinases. Furthermore, the activity of lamellipodial waves can be modulated by Mek1, independently of leading edge activity. The ability to selectively regulate cell migration via lamellipodial waves has implications for manipulating the migratory behavior of OECs during neural repair
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    Journal Title
    Glia
    Volume
    55
    Issue
    16
    Publisher URI
    https://onlinelibrary.wiley.com/toc/10981136/2007/55/16
    DOI
    https://doi.org/10.1002/glia.20586
    Subject
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/26638
    Collection
    • Journal articles

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