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  • Nearly neutrality and the evolution of codon usage bias in eukaryotic genomes

    Author(s)
    Subramanian, Sankar
    Griffith University Author(s)
    Sankarasubramanian, Sankar
    Year published
    2008
    Metadata
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    Abstract
    Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome, is largely similar across eukaryotes ranging from unicellular protists to vertebrates. Conversely, this bias in housekeeping genes and in highly expressed genes has a remarkable inverse relationship with species generation time that varies by more than four orders of magnitude. The relevance of these results to the nearly neutral theory of molecular evolution is discussed.Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome, is largely similar across eukaryotes ranging from unicellular protists to vertebrates. Conversely, this bias in housekeeping genes and in highly expressed genes has a remarkable inverse relationship with species generation time that varies by more than four orders of magnitude. The relevance of these results to the nearly neutral theory of molecular evolution is discussed.
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    Journal Title
    Genetics
    Volume
    178
    Issue
    4
    Publisher URI
    http://www.genetics.org/
    DOI
    https://doi.org/10.1534/genetics.107.086405
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Genetics
    Publication URI
    http://hdl.handle.net/10072/26643
    Collection
    • Journal articles

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