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  • Phosphoproteomics a possible route to novel biomarkers of breast cancer

    Author(s)
    Metodiev, Metodi
    Alldridge, Louise
    Griffith University Author(s)
    Alldridge, Louise C.
    Year published
    2008
    Metadata
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    Abstract
    Proteomics is rapidly transforming the way that cancer and other pathologies are investigated. The ability to identify hundreds of proteins and to compare their abundance in different clinical samples presents a unique opportunity for direct identification of novel disease markers. Furthermore, recent advances allow us to analyse and compare PTMs. This gives an additional dimension for defining a new class of protein biomarker based not only on abundance and expression but also on the occurrence of covalent modifications specific to a disease state or therapy response. Such modifications are often a consequence of the ...
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    Proteomics is rapidly transforming the way that cancer and other pathologies are investigated. The ability to identify hundreds of proteins and to compare their abundance in different clinical samples presents a unique opportunity for direct identification of novel disease markers. Furthermore, recent advances allow us to analyse and compare PTMs. This gives an additional dimension for defining a new class of protein biomarker based not only on abundance and expression but also on the occurrence of covalent modifications specific to a disease state or therapy response. Such modifications are often a consequence of the activation/inactivation of a particular disease related pathway. In this review we evaluate the available information on breast cancer related protein-phosphorylation events, illustrating the rationale for investigating this PTM as a target for breast cancer research with eventual clinical relevance. We present a critical survey of the published experimental strategies to study protein phosphorylation on a system wide scale and highlight recent specific advances in breast cancer phosphoproteomics. Finally we discuss the feasibility of establishing novel biomarkers for breast cancer based on the detection of patterns of specific protein phosphorylation events.
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    Journal Title
    Proteomics - Clinical Applications
    Volume
    2
    Issue
    2
    DOI
    https://doi.org/10.1002/prca.200780011
    Subject
    Cancer Cell Biology
    Medical Biochemistry and Metabolomics
    Publication URI
    http://hdl.handle.net/10072/26682
    Collection
    • Journal articles

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