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dc.contributor.authorNikolakopoulos, George
dc.contributor.authorFigler, Heidi
dc.contributor.authorLinden, Joel
dc.contributor.authorJ. Scammells, Peter
dc.date.accessioned2017-05-03T14:02:38Z
dc.date.available2017-05-03T14:02:38Z
dc.date.issued2006
dc.date.modified2010-07-22T06:52:33Z
dc.identifier.issn09680896
dc.identifier.doi10.1016/j.bmc.2005.11.018
dc.identifier.urihttp://hdl.handle.net/10072/26786
dc.description.abstractThree series of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene and 2-amino-5,6,7,8-tetrahydrocyclohepta[b]thiophenes with 3-carboxylates and carboxamides have been prepared using the Gewald synthesis and evaluated as A1AR allosteric enhancers. The structure-activity relationships of these classes of compound are described. A number of compounds, notably 7b, are more potent and efficacious than PD81,723.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon Press
dc.publisher.placeOxford, UK
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom2358
dc.relation.ispartofpageto2365
dc.relation.ispartofissue7
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode1115
dc.title2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorNikolakopoulos, George


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